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، جلد ۱۶، شماره ۴، صفحات ۲۳۷-۲۴۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Black Seed Oil Protects Against Levofloxacin Hepatotoxicity: Analyses of the Biochemical and Histopathological Effects |
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| چکیده انگلیسی مقاله |
Background: Long-term use of levofloxacin can cause alterations in the liver function. This study aimed to determine the protective effect of black seed oil (BSO) against liver injury due to levofloxacin administration in rats. Methods: The chemical composition of BSO was analyzed with gas chromatography and mass spectrophotometry (GC-MS). Rats (n=30) were treated daily with levofloxacin and BSO at three doses (1, 2 or 4 mL/kg) orally for 28 days. The presence of liver injury was determined based on serum biomarkers and liver malondialdehyde (MDA) levels, and histopathological examinations. Results: The GC-MS analyses showed that BSO contained 25 chemical compounds, including thymoquinone (10.14%). The levofloxacin administration significantly increased the liver enzymes and MDA levels, and induced a marked alteration in the liver histological structures. Treatments of rats with one or two mL/kg BSO significantly decreased the liver enzymes, and MDA levels compared to those that received levofloxacin alone (P< 0.05). However, the highest dose (4 mL/kg) BSO failed to improve liver MDA levels. The recovery of liver histological damages was also observed in rats treated with BSO. Conclusion: It was concluded that the BSO administration reduced the liver dysfunction due to levofloxacin at doses of 1 or 2 mL/kg, but not at 4 mL/kg. Further research is warranted to explore if the protective effect of BSO is associated with its antioxidant properties. |
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| کلیدواژههای انگلیسی مقاله |
Black seed oil, Histopathology, Levofloxacin, Liver injury, Nigella Sativa |
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| نویسندگان مقاله |
| Nurfadilah Nurfadilah
Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia.
| Yulia Yusrini Djabir
Laboratory of Clinical Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia.
| Siti Aminah
Laboratory of Clinical Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia.
| Yulita Chrismensi Patimang
Laboratory of Clinical Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia.
| Arif Santoso
Department of Pulmonology, Faculty of Medicine, Hasanuddin University, Indonesia, Makassar.
| Risfah Yulianty
Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia.
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| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-854-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
پژوهشی |
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