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، جلد ۱۴، شماره ۴، صفحات ۲۵۳-۲۶۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Determination of Amphetamine and Methamphetamine by Dispersive Liquid Phase Micro-extraction: A Novel Experimental Approach |
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| چکیده انگلیسی مقاله |
Background: A syringe to syringe dispersive liquid phase micro-extraction-floating organic drop was applied and used for the simultaneous extraction and pre-concentration of trace amounts of amphetamine (AMP) and methamphetamine (MAMP) in urine samples. The extracted analytes were determined by high performance liquid chromatography along with diode array detection. Methods: In this study, n-hexane was selected as the extraction solvent without the need to use dispersive solvent. The analytical parameters affecting the micro-extraction efficiency, including pH of sample solution, extraction solvent volume, the cycles of extraction and time of centrifugation were investigated and optimized by screening and optimization experimental design methods. Results: Underoptimal conditions, the calibration curve had a linear range of 2-100 μg/L with the determination coefficient of R2=99.8 and R2=99.6 for AMP and MAMP, respectively. The limit of detection was 2 μg/L for AMP and MAMP, and the enrichment factor was 75 and 68 for AMP and MAMP, respectively. Conclusion: This method is very simple, rapid and has been successfully used for pre-concentration and measurement of the analytes in urine samples, which is important to forensic studies. |
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| کلیدواژههای انگلیسی مقاله |
Dispersive liquid-phase micro-extraction, Amphetamine, Methamphetamine, Experimental design, Forensic medicine |
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| نویسندگان مقاله |
| Daruish Badakhshan
Department of Chemistry, Faculty of Science, Arak Branch, Islamic Azad University, Arak, Iran.
| Majid Ramezani
Department of Chemistry, Faculty of Science, Arak Branch, Islamic Azad University, Arak, Iran.
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| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-693-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
تخصصی |
| نوع مقاله منتشر شده |
کاربردی |
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