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، جلد ۹، شماره ۲، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Synthesis and characterization of ciprofloxacin loaded histidine modified chitosan nanoparticle for eradication of Pseudomonas aeroginosa biofilm |
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| چکیده انگلیسی مقاله |
Background: Pseudomonas aeruginosa biofilm is one of the problems in antibiotic treatment of infections. Nanomedicines such as chitosan can carry multiple drugs and improve the therapeutic effects of antibiotics. Objectives: The study aimed to synthesis and characterization of ciprofloxacin loaded chitosan nanoparticle for eradication biofilm of P. aeroginosa. Methods: Cipro-CS microparticles were prepared by ionic gelation method and their size, zeta potential, and drug release pattern were determined. MBEC and MBIC of different groups of antibiotic (Ciprofloxacin, Ciprofloxacin & PAβN, CS Ciprofloxacin, and CS Ciprofloxacin & PAβN) were performed on biofilm samples of P. aeroginosa. Results: Ciprofloxacin loading efficiency was 35.51%, and encapsulation efficiency was 55.06%. Released ciprofloxacin from CS nanoparticles was %80 after 24 hours. Biofilm production was positive in %96.7 of the isolates while %30.1 of the samples had strong biofilm. The best result for MBIC was CS Ciprofloxacin, CS Ciprofloxacin & PAβN, Ciprofloxacin & PAβN, and Ciprofloxacin respectively. For MBEC the result was slightly different and from the best to better CS Ciprofloxacin & PAβN, CS Ciprofloxacin, Ciprofloxacin & PAβN, and Ciprofloxacin. Conclusion: Today, with increasing antibiotic resistance, there are many challenges in treating infections. Due to the role of biofilm in antibiotic resistance, researchers are looking for new antibiotics to treat infections. |
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| کلیدواژه‌های انگلیسی مقاله |
Chitosan, Nanoparticle, Biofilm, Pseudomonas aeroginosa |
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| نویسندگان مقاله |
| foroogh faridi
Department of Microbiology, College of Science, Agriculture and Modern Technology , Shiraz Branch, Islamic Azad University, Shiraz, Iran
| nima bahador
Department of Microbiology, College of Science, Agriculture and Modern Technology , Shiraz Branch, Islamic Azad University, Shiraz, Iran
| saeed shoja
Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
| sahar abbasi
Department of Pharmaceutics, Faculty of Pharmacy, Hormozgan University of Medical sciences, Bandar Abbas, Iran
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| نشانی اینترنتی |
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-1112-1&slc_lang=en&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
پژوهشی |
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