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Basic and Clinical Neuroscience، جلد ۱۴، شماره ۳، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Glucagon Like Peptide-1 and Its Receptor in Human Brain: Distribution of Expression, Functional Implications, Age Related Changes & Species Specific Characteristics |
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| چکیده انگلیسی مقاله |
Emerging evidence has shown that the Glucagon like peptide-1 (GLP-1) agonist can be used for treating Alzheimer's disease, but knowledge of its neural targets is limited. To understand the neural substrates of GLP-1, we have done whole brain mapping for GLP-1 and its receptor (GLP-1R), in 30 human brains. GLP-1 expression was studied by immuno-histochemistry and confirmed by western blot method. GLP-1R gene expression was studied by RT-PCR. GLP-1 expression was seen in most of the cortical areas (maximum in frontal, prefrontal & parietal cortex), diencephalon and brainstem, but not in cerebellum. Protein expression studies validated these results. Highest expression of GLP-1R was found in the frontal cortex. The orbito-frontal cortex and cerebellum had negligible expression. Hippocampus demonstrated significant presence of GLP-1R but patchy immunoreactivity to GLP-1. GLP-1R presence in most of the human cortical regions and absence in cerebellum is the major deviation from the animal brain. Sites which might be of interest in Alzheimer's have been identified. GLP-1 demonstrated age related decline in most of the areas after 5thdecade. At 60yrs GLP-1 was not found in any of the cortical areas except in the prefrontal cortex but it was present in the sub-cortical areas. Age related profiling of GLP-1 in various brain areas has been analysed, which can have important bearing on understanding the Alzheimer's. This study provides detailed description of GLP-1 and GLP-1R locations by complete human brain mapping for the first time and may lead to novel treatment options targeting the GLP-1 receptors. |
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| کلیدواژه‌های انگلیسی مقاله |
Glucagon like peptide-1, Glucagon like peptide -1 receptor, Alzheimer’s disease, Human brain |
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| نویسندگان مقاله |
| Tulika Gupta
Department of Anatomy, Post Graduate Institute of Medical Education and Research, Chandigarh-160012, India.
| Mandeep Kaur
Department of Anatomy, Post Graduate Institute of Medical Education and Research, Chandigarh-160012, India.
| Devendra Shekhawat
Department of Anatomy, Post Graduate Institute of Medical Education and Research, Chandigarh-160012, India.
| Ritu Aggarwal
Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh-160012, India.
| Neha Nanda
Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh-160012, India.
| Daisy Sahni
Department of Anatomy, Post Graduate Institute of Medical Education and Research, Chandigarh-160012, India.
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-2554-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cellular and molecular Neuroscience |
| نوع مقاله منتشر شده |
Original |
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