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Caspian Journal of Neurological Sciences، جلد ۱، شماره ۲، صفحات ۳۷-۵۱
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Cell Therapy for Traumatic Brain Injury: Opportunities and Pitfalls |
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| چکیده انگلیسی مقاله |
Today, stem cell transplantation is a hot topic in scientific circles as a novel therapeutic approach to repair the structure and function of central nervous system. The safe and neuroprotective effects of cell therapy in models and traumatic brain injury patients were evaluated in many experimental and clinical studies in recent decade and somewhat promising results were provided to the scientific community. Nevertheless, there are still obstacles in translating experimental studies in the laboratory into clinical practice that should not be overlooked. In this review study, a brief explanation is provided about biological events and endogenic neurogenesis and angiogenesis after TBI the performance of transplanted cells in restoration of damaged neurons the role and potential use of mesenchymal stem cells as adult stem cells preferred in cell transplantation and clinical trials ever conducted in this area features of cell transplant candidates who will most benefit from transplantation, the type of and proper time for cell transplantation, optimal method for conducting transplant to deliver cells to the brain, and the best dose for effectiveness of transplantation. Finally, the various neuroimaging techniques are discussed, which are used to track and evaluate the survival and implantation of transplanted cells. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
سارا رمضانی | sara ramezani
neuroscience department, school of advanced technologies in medicine, tehran university of medical sciences, tehran, iran ; s.ramezanislp@gmail.com
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
زهیر ریحانیان | zoheir reihanian
neurosurgery department, guilan university of medical sciences, rasht, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)
محمد تقی جغتایی | mohammad taghi joghataei
neuroscience department, school of advanced technologies in medicine, iran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
شاهرخ یوسف زاده | shahrokh yousefzadeh
neurosurgery department, guilan road trauma research center, guilan university of medical sciences, rasht, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)
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| نشانی اینترنتی |
http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-17&slc_lang=en&sid=en |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/1782/article-1782-282264.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
تخصصی |
| نوع مقاله منتشر شده |
مروری |
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