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، جلد ۱۷، شماره ۳، صفحات ۶۰-۶۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Chronic Toxicity of Purwoceng Root Extract: The Biochemical and Histopathological Effects on Rat Liver and Kidneys |
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| چکیده انگلیسی مقاله |
Background: Purwoceng, a native Indonesian plant, has been traditionally used for its aphrodisiac, diuretic, and tonic effects. Despite its long history, the chronic effects of Purwoceng have not been fully understood. This study analyzed the chronic toxicity effects of the ethanol extracts of Purwoceng roots on the liver and kidneys in white male rats. Methods: We conducted post-tests for liver histopathology and pre- & post-tests for SGOT, SGPT and urea-creatinine levels. The treatments were administered over 90 days on 32 rats, which were randomly divided into four groups, consisting of a control group (A), and three treatment groups receiving doses of 21 mg/kg/day (B), 42 mg/kg /day (C), and 84 mg/kg/day (D). Results: The chronic administration of Purwoceng root extracts at various doses did not significantly increase the SGOT and SGPT levels, but increased the levels of urea and creatinine at 21 and 42 mg/kg/day, respectively. The histopathological analyses revealed that the extracts caused some cellular damages in the liver at 42 mg/kg/day. The minimal toxic dose for the chronic administration of the extract was 21 mg/kg/day. However, determining a safe dose for the chronic administration of the extract was not possible, as even the control group showed increases in SGOT, SGPT and urea-creatinine levels. However, at 21 mg/kg/day, the extract did not cause liver histological damages. Conclusion: The chronic administration of Purwoceng extract did not affect the liver function but caused histological damages in the liver cells and affected the kidneys function. |
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| کلیدواژههای انگلیسی مقاله |
Biochemical, Chronic Toxicity, Extract, Histopathological Effects, Purwoceng Roots |
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| نویسندگان مقاله |
| Fitranto Arjadi
Anatomy Department, Jenderal Soedirman University. Purwokerto, Indonesia
| Ika Murti Harini
Department of Histology, Medical Faculty, JendralSoedirman University. Purwokerto, Indonesia
| Alfi Muntafiah
Department of Biochemistry, Medical Faculty, JendralSoedirman University. Purwokerto, Indonesia
| Setiawati Setiawati
Department of Pharmacology, Medical Faculty, Jendral Soedirman University. Purwokerto, Indonesia
| Mulyoto Pangestu
Education Program in Reproduction and Development, Department of Obstetrics and Gynecology, Monash Clinical School, Monash University. Monash, Australia
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| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1090-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
پژوهشی |
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