| چکیده انگلیسی مقاله |
Background: Environmental pollutants, such as plastic-derived substances Bisphenol-A (BPA) and Di-butyl phthalate (DBP), have been linked to an increase in the occurrence of human health hazard including lipid dysmetabolism and organ toxicity. This study was designed to investigate the hepato-renal toxic effect of plasticizers and the possible intervention role of rutin in rat. Materials and Methods: Eighteen rats were randomized into 3 groups of 6 animals each and were treated as follows for 28 days: Control (0.1% DMSO), Bisphenol-A and Dibutyl phthalate (BPA 25 mg/kg + DBP 25 mg/kg, p.o), Bisphenol-A, Dibutyl phthalate and rutin (BPA 25 mg/kg + DBP 25 mg/kg + Rt 50 mg/kg, p.o). Hepatic and renal toxic biomarkers, redox status and lipid profile were measured. Results: The plasticizers toxicity led to increase in GGT, urea, renal MDA and significant reduction in SOD and CAT activities relative to control. Total cholesterol and low-density lipoprotein (LDL) levels in the plasma increased. Hepatic total cholesterol, LDL, FFA, TG levels increased and HDL decreased while total cholesterol, TG and LDL levels increased in the kidney. However, these alterations were ameliorated by rutin in the plasticizers-treated rats. Conclusion: Flavonoid, rutin demonstrated hepato-renal protective effect against the assaults from plasticizers exposure. |
| نویسندگان مقاله |
| Olufemi Oluranti
Department of Physiology, College of Health Sciences, Bowen University, P.M.B. 284, Iwo, Nigeria
| Praise Akin-Aborishade
Department of Physiology, College of Health Sciences, Bowen University, P.M.B. 284, Iwo, Nigeria
| Atilola Olarinde
Department of Physiology, College of Health Sciences, Bowen University, P.M.B. 284, Iwo, Nigeria
| Babatunde Alabi
Department of Pharmacology and Therapeutics, College of Health Sciences, Bowen University, P.M.B. 284, Iwo, Nigeria
| Esther Ojo-Ayangoke
Department of Physiology, College of Health Sciences, Bowen University, P.M.B. 284, Iwo, Nigeria
| Timilehin Mayowa
Department of Physiology, College of Health Sciences, Bowen University, P.M.B. 284, Iwo, Nigeria
| Marvelous Paseda
Department of Physiology, College of Health Sciences, Bowen University, P.M.B. 284, Iwo, Nigeria
| Ayomide Lawal
Department of Physiology, College of Health Sciences, Bowen University, P.M.B. 284, Iwo, Nigeria
| Ibukun Dahunsi
Department of Physiology, College of Health Sciences, Bowen University, P.M.B. 284, Iwo, Nigeria
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