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Pharmaceutical and Biomedical Research، جلد ۹، شماره ۳، صفحات ۱۶۹-۱۷۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effectiveness of 5-aminolevulinic Acid-mediated Photodynamic Therapy Combined With Curcumin |
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| چکیده انگلیسی مقاله |
5-Aminolevulinic acid (5-ALA) is the mitochondria metabolite produced from glycine and succinyl-CoA, which is converted to protoporphyrin IX (PpIX) by the conjugation of eight itself molecules forming the "heme" group in the porphyrin ring (Figure 1) [1]. The PpIX is used as a photosensitizer (PS) with an absorption wavelength of 410 nm, and 5-ALA acts as a precursor or prodrug for PpIX in photodynamic therapy (PDT). Exogenous administration of excessive amounts of 5-ALA increases the production of PpIX during heme biosynthesis. It is eliminated after 24-48 h with a lower risk of long-term photosensitivity [2]. However, ALA/PDT has several disadvantages. For instance, the concentration of ALA is affected by its absorption and pharmacokinetics that do not fully cover the treatment area [3-5]. It also limits the depth of tumor penetration and causes pain [6]. |
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| کلیدواژه‌های انگلیسی مقاله |
5-Aminolevulinic Acid, Photosensitizer, Photodynamic therapy, Curcumin |
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| نویسندگان مقاله |
| Siu Kan Law
Faculty of Science and Technology, The Technological and Higher Education Institute of Hong Kong, Tsing Yi, Hong Kong.
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| نشانی اینترنتی |
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-1057-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
ترکیبات طبیعی |
| نوع مقاله منتشر شده |
Letter to Editor |
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