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The Judishapur Journal of Oncology، جلد ۲، شماره ۲، صفحات ۳۸-۴۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The Association Between H. pylori Antibodies as a Risk of Gastric Cancer and Vitamin D Levels |
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| چکیده انگلیسی مقاله |
Objectives: Helicobacter pylori (H. pylori) infection is a significant cause of chronic
gastritis. Various studies have reported a link between H. pylori and vitamin D levels. Most
showed the effect of serum levels of 25 hydroxy vitamin D (25[OH]D) on the eradication
of H. pylori infection. In the present study, we aimed to assess the association between
vitamin D serum levels and various types of antibodies against H. pylori infection. It
is well recognized that H. pylori infection is the most important risk factor for gastric
adenocarcinoma. Furthermore, vitamin D deficiency may be associated with a poor
prognosis in gastric cancer.
Methods: In the present laboratory-based retrospective study, the medical records of
random individuals referred for screening to the Negaresh Pathobiology Laboratory in
Tehran, Iran, from 2019 to 2021 were retrospectively reviewed. A total of 196 subjects
were eligible for evaluation and were enrolled. The serum concentration of Vitamin D
was determined quantitatively via a fully automated enzyme-linked immunosorbent assay
(ELISA), and H. pylori IgG, IgM, and IgA antibodies were analyzed quantitatively by
using the ELISA microplate reader.
Results: According to our results, the serum levels of 25(OH)D did not change significantly
in different groups of patients with different levels of H. pylori IgG, IgM, and IgA antibodies.
Discussion: The relationship between vitamin D and H. pylori remains to be determined.
In conclusion, no significant relationship was identified between the level of vitamin D and
the amount of different anti-H pylori antibodies, including IgG, IgM, and IgA.
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| کلیدواژه‌های انگلیسی مقاله |
Anti-Helicobacter pylori antibody,
Helicobacter pylori,
Vitamin D |
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| نویسندگان مقاله |
Reza Ghanbari |
Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Science, Tehran, Iran
Mehrdad Haghighi |
Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Amir Mohammad Alborzi |
Cancer Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
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| نشانی اینترنتی |
https://jjo.ajums.ac.ir/article_167555_831d9d35225fe6e0b41b01a39ffbe910.pdf |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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