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Immunoregulation، جلد ۳، شماره ۱، صفحات ۳-۱۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Role of MicroRNAs in BCG Therapy by the Induction of Neutrophil Extracellular Traps in Bladder Cancer |
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| چکیده انگلیسی مقاله |
The treatment of bladder cancer is usually performed by Bacillus Calmette-Guerin (BCG) instillation. BCG therapy is a common therapeutic method with fewer side effects compared with chemotherapy, radiotherapy, etc. BCG can also inhibit the progression and recurrence of bladder cancer by inducing apoptosis pathways, arrest cell cycle, autophagy, and neutrophil extracellular traps (NETs) formation. However, BCG therapy cannot be effective in the situation that the metastasis occurs. NETs are induced by BCG and help suppress the growth of tumor cells, especially in the primary stages of bladder cancer. Activated neutrophils can stimulate cellular pathways, such as autophagy and NETs release in the presence of microbial pathogenesis, inflammatory agents, and tumor cells. Autophagy can also regulate NETs formation and induce Reactive Oxygen Species (ROS) and NETs production. Moreover, miRNAs are key regulators of gene expression. These small non-coding RNAs are also considered as an essential factor in controlling tumor development. The interaction between BCG and miRNAs is still unclear. However, in the present study and for the first time, we intend to discuss the role of miRNAs in BCG therapy and how NETs formation can be effective on BCG performance to treat the bladder cancer. |
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| کلیدواژه‌های انگلیسی مقاله |
Bladder cancer,
Bacillus Calmette-Guerin (BCG),
Neutrophil extracellular traps (NETs),
MicroRNAs (miRNAs) |
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| نویسندگان مقاله |
Mohammad Mehdi Adibzadeh Sereshgi |
Department of Immunology, Shahed University, Tehran, Iran.
Ali Mohammad Mohseni Majd |
Immunoregulation Research Center, Shahed University, Tehran, Iran.
Sahar Salimi |
Immunoregulation Research Center, Shahed University, Tehran, Iran.
Hassan Noorbazargan |
Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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| نشانی اینترنتی |
https://immunoreg.shahed.ac.ir/article_1221_c8a1de30bdf7dad5f6fd696bc9fd7ef5.pdf |
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| زبان مقاله منتشر شده |
en |
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