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Iranian Journal of Veterinary Medicine، جلد ۱۸، شماره ۱، صفحات ۲۳-۳۲
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| عنوان فارسی |
اثرهلی کریسوم پلیکاتوم( helichrysum plicatum)روی کبد چرب غیر الکلی ناشی از فروکتوز |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effect of Helichrysum plicatum Subs. plicatum on Fructose-induced Nonalcoholıc Fatty Liver |
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| چکیده انگلیسی مقاله |
Background: The Helichrysum genus of the Asteraceae family comprises 500 species. Fifteen Helichrysum species are found in Turkey. This genus is used in traditional medicine for several beneficial effects.
Objectives: This study explored Helichrysum plicatum subsp. plicatum (HPsP) effects on fructose-induced nonalcoholic fatty liver disease (NAFLD).
Methods: Thirty-five adult male Wistar rats weighing 200–250 g were divided into 5 groups: Control, HPsP, fructose (F), HPsP+fructose, and double-dose HPsP+fructose. Fructose (40%) was then added to the water. HPsP extract was administered at doses of 4 and 8 mg/kg. All treatments were performed for 8 weeks.
Results: The F, F+HPsP, and double-dose groups exhibited higher palmitic acid (16:0) levels than the control group (P<0.001). F+HPsP treatment enhanced palmitoleic acid levels (P<0.001). The F and F+HPsP groups showed reduced levels of linolenic (18:3 n-3), eicosadienoic (20:2, n-6), and arachidonic (20:4 n-6) acids (P<0.001, P<0.01, and P<0.05, respectively). The F, F+HPsP, and double-dose groups showed lower docosahexaenoic acid (22:6, n-3) levels (P<0.05). Retinol and in HPsP treated group and (P<0.05) K1 vitamin levels increased in all groups compared to control group (P<0.001). The F, F+HPsP, and HPsP groups had lower vitamin K-2 and D-3 levels (P<0.001 and P<0.01, respectively). The F, HPsP, F+HPsP, and double-dose groups had higher cholesterol levels (P<0.05, P<0.01, P<0.001, respectively).
Conclusion: HPsP extract altered fructose-induced fatty liver composition and levels of reduced glutathione and vitamins A, D, E, and K. Unexpectedly, high liver cholesterol levels require treatment.
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| کلیدواژه‌های انگلیسی مقاله |
Fructose,
Helichrysum plicatum,
Lipophilic vitamins,
NAFLD,
Omega-3 |
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| نویسندگان مقاله |
Mehmet Guvenc |
Department of Biology, Faculty of Science, Adiyaman University, Adiyaman, Turkey.
Ibrahim Dogan |
Department of Biology, Faculty of Science, Adiyaman University, Adiyaman, Turkey.
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| نشانی اینترنتی |
https://ijvm.ut.ac.ir/article_95365_33de535ee3f35e9efe91f65db6b0e6a4.pdf |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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