Iranian Journal of Veterinary Medicine، جلد ۱۸، شماره ۱، صفحات ۲۳-۳۲

عنوان فارسی اثرهلی کریسوم پلیکاتوم( helichrysum plicatum)روی کبد چرب غیر الکلی ناشی از فروکتوز
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عنوان انگلیسی Effect of Helichrysum plicatum Subs. plicatum on Fructose-induced Nonalcoholıc Fatty Liver
چکیده انگلیسی مقاله Background: The Helichrysum genus of the Asteraceae family comprises 500 species. Fifteen Helichrysum species are found in Turkey. This genus is used in traditional medicine for several beneficial effects.
Objectives: This study explored Helichrysum plicatum subsp. plicatum (HPsP) effects on fructose-induced nonalcoholic fatty liver disease (NAFLD). 
Methods: Thirty-five adult male Wistar rats weighing 200–250 g were divided into 5 groups: Control, HPsP, fructose (F), HPsP+fructose, and double-dose HPsP+fructose. Fructose (40%) was then added to the water. HPsP extract was administered at doses of 4 and 8 mg/kg. All treatments were performed for 8 weeks.
Results: The F, F+HPsP, and double-dose groups exhibited higher palmitic acid (16:0) levels than the control group (P<0.001). F+HPsP treatment enhanced palmitoleic acid levels (P<0.001). The F and F+HPsP groups showed reduced levels of linolenic (18:3 n-3), eicosadienoic (20:2, n-6), and arachidonic (20:4 n-6) acids (P<0.001, P<0.01, and P<0.05, respectively). The F, F+HPsP, and double-dose groups showed lower docosahexaenoic acid (22:6, n-3) levels (P<0.05). Retinol and in HPsP treated group and (P<0.05) K1 vitamin levels increased in all groups compared to control group (P<0.001). The F, F+HPsP, and HPsP groups had lower vitamin K-2 and D-3 levels (P<0.001 and P<0.01, respectively). The F, HPsP, F+HPsP, and double-dose groups had higher cholesterol levels (P<0.05, P<0.01, P<0.001, respectively).
Conclusion: HPsP extract altered fructose-induced fatty liver composition and levels of reduced glutathione and vitamins A, D, E, and K. Unexpectedly, high liver cholesterol levels require treatment.
 
کلیدواژه‌های انگلیسی مقاله Fructose, Helichrysum plicatum, Lipophilic vitamins, NAFLD, Omega-3

نویسندگان مقاله Mehmet Guvenc |
Department of Biology, Faculty of Science, Adiyaman University, Adiyaman, Turkey.

Ibrahim Dogan |
Department of Biology, Faculty of Science, Adiyaman University, Adiyaman, Turkey.


نشانی اینترنتی https://ijvm.ut.ac.ir/article_95365_33de535ee3f35e9efe91f65db6b0e6a4.pdf
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