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Research in Molecular Medicine، جلد ۱۰، شماره ۴، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Upregulated Expression of Runt-Related Transcription Factor 3 and Interferon Regulatory Factor 4 Genes in Patients With Ankylosing Spondylitis |
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| چکیده انگلیسی مقاله |
Background: Ankylosing spondylitis (AS) is a debilitating autoimmune disease presented by chronic inflammation of large joints and central skeleton. The role of various immune cells including T cell subsets has been studied in the pathogenesis of AS. Two critical transcription factors, runt-related transcription factor 3 (RUNX3) and interferon regulatory factor 4 (IRF4), have been shown to be involved in the differentiation and function of T lymphocytes. This study aimed to compare the gene expression level of RUNX3 and IRF4 between patients with ankylosing spondylitis and healthy subjects to understand the impact of these factors in the immunopathogenesis of the disease.
Method: Thirty patients with AS and 30 age and gender-matched healthy individuals were recruited to the study and expression of RUNX3 and IRF4 genes was evaluated using the RT-PCR technique in their peripheral blood.
Results: The expression of RUNX3 and IRF4 genes in AS patients were significantly upregulated compared to the healthy controls (P.value: 0.03 and 0.025 respectively). In addition, there was a direct correlation between IRF4 gene expression and Bath Ankylosing Spondylitis Global Score (BAS-G) (Correlation Coefficient = 0.38, P.value: 0.04)
Conclusion: Gene expression of transcription factors RUNX3 and IRF4, which are involved in the differentiation and function of T cells, was increased in ankylosing spondylitis. These findings might have prognostic and therapeutic value. |
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| کلیدواژه‌های انگلیسی مقاله |
Ankylosing Spondylitis, Interferon Regulatory Factors 4, Quality of life, Runt-Related Transcription Factor 3 |
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| نویسندگان مقاله |
| sara Assadiasl
tehran university of medical sciences, molecular immunology research center
| Narjes Soleimanifar
tehran university of medical sciences, molecular immunology research center
| Abdolrahman Rostamian
Department of Rheumatology, Imam Khomeini Hospital, Tehran University of Medical Sciences
| Maryam Sadr
tehran university of medical sciences, molecular immunology research center
| Hanieh Mojtahedi
tehran university of medical sciences, molecular immunology research center
| Maryam Ahmadi
Department of Immunology, School of Medicine, Tehran University of Medical Sciences
| Abeda Mazari
Department of Immunology, School of Medicine, Tehran University of Medical Sciences
| Mohammad Hossein Nicknam
tehran university of medical sciences, molecular immunology research center
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| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1270-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
ایمونولوژی |
| نوع مقاله منتشر شده |
پژوهشی |
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