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Basic and Clinical Neuroscience، جلد ۱۵، شماره ۱، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
The Effect of Omega-3 Supplementation on Serum Levels of Antioxidant Status in Patients with Bipolar Disease |
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| چکیده انگلیسی مقاله |
Background and Objectives: Antioxidants prevent the progression of neuropsychiatric disorders, such as bipolar disorder (BD). Omega-3 fatty acid supplementation helps prevent lipid peroxidation and improve antioxidant status. This study aims to investigate the effect of omega-3 supplementation on serum levels of antioxidant status in patients with BD.
Methods: In this study, 28 patients with BD received an omega-3 fatty acid supplement (2 g/daily) while the other 28 patients received edible paraffin oil (2 g/daily) for 60 days. The activities of superoxide dismutase (SOD), catalase (CAT), and total antioxidant capacity (TAC) were evaluated in pre-intervention and post-intervention.
Results: The results showed that omega-3 supplementation increased the activities of SOD (12.94 ± 3.84 U/mL vs 17.72 ± 3.59 U/mL) and CAT (5.08 ± 1.61 nmol/min/mL vs 6.43 ± 1.33 nmol/min/mL) in post-intervention compared to pre-intervention (P = 0.001). The results also showed that omega-3 supplementation increased the activities of SOD (17.72 ± 3.59 U/mL vs 13.79 ± 3.12 U/mL) and CAT (6.43 ± 1.33 nmol/min/mL vs 4.89 ± 1.45 nmol/min/mL) compared to the control group in post-intervention (P = 0.001). Omega-3 supplementation did not have significant effects on the serum concentration of total antioxidant capacity (TAC) compared to pre-intervention (P = 0.373) and control group (P = 0.604).
Conclusion: Omega-3 supplementation increased the activities of SOD and CAT and may decrease the progression of disease via increasing antioxidant status. |
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| کلیدواژههای انگلیسی مقاله |
Antioxidant capacity, Bipolar disease (BD), Catalase (CAT), Omega-3 |
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| نویسندگان مقاله |
| Dina Gholipour
Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
| Mansour Shahraki
Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
| Mohsen Saravani
Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
| Abolfazl Payandeh
Community Nursing Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
| Hadi Eslahi
Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-4292-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Clinical Neuroscience |
| نوع مقاله منتشر شده |
Original |
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