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Anatomical Sciences Journal، جلد ۲۰، شماره ۱، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
The Effects of High-Intensity Interval and Moderate-Intensity Continuous Trainings on Autophagy, Cardiac Remodeling and Heart Function in Aged Male Rats |
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| چکیده انگلیسی مقاله |
Introduction: Aging is a physiological process affecting the heart function. Training is known as a factor accelerating the heart output specially in aged individuals. In the present experimental study, the authors aimed to assess the role of High-intensity interval training (HIIT) and Moderate-intensity continuous training (MICT) on autophagy, cardiac remodeling and cardiac function.
Methods: 24 aged (≈20 months) male Wistar rats were divided into 3 groups of Control, HIIT and MICT. The special trainings of high-intensity interval and Moderate-intensity continuous were for 8 weeks. Aerobic power and training capacity were also assessed. 2 dimensional echocardiography was also applied for assessment of cardiac indices. At the end of the experiment, tissue sampling of cardiac tissue was applied and gene expression was assessed using qRT-PCR technique. Data were analyzed using SPSS (v.19) software.
Results: After HIIT and MICT trainings, no significant changes were detected regarding the animal weight. Also, mTORC1, Atg16, and Atg7 gene expression and EF and FS were accelerated in HIIT and MICT groups than control animals. Besides, COLIII gene expression, LVEDD, and LVESD were increased significantly (p<0.05) in HIIT and MICT animals than control.
Conclusion: Training can potentially improve the cardiac output in elderly. Besides, the HIIT seems effective than MICT. |
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| کلیدواژههای انگلیسی مقاله |
Aging, cardiac output, echocardiography, High-intensity interval training, Moderate-intensity continuous training, mTORC1, Atg16, Atg7, COLIII, LVEDD, LVESD, EF, FS |
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| نویسندگان مقاله |
| Azadeh Taheri
Phd Candidate of Exercise Physiology, Department of Exercise Physiology, Science and Research Branch, Islamic Azad University, Tehran, Iran. Phone: +989917600144. Mail: azadetaheri1992@gmail.com. ORCID: 0000-0002-3609-3996.
| Behzad Bazgir
Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. Phone: +989334781110. Mail: Bazgirbehzad@yahoo.com & Bazgirbehzad@bmsu.ac.ir. ORCID:0000-0002-5128-7617.
| Hossein Abednatanzi
Assistant Professor, Department of Professional Physical Education and Sport Science, Science and Research Branch, Islamic Azad University, Tehran, Iran. Phone: +989126107064. Mail: abednazari@gmail.com & h-abednatanzy@srbiau.ac.ir. ORCID: 0000-0001-6638-1131.
| Mandana Gholami
Associate professor, Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran. Phone: +989121491868. Mail: Gholami_man@yahoo.com.
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| نشانی اینترنتی |
http://anatomyjournal.ir/browse.php?a_code=A-10-415-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Gross Anatomy |
| نوع مقاله منتشر شده |
Original |
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