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Pharmaceutical and Biomedical Research، جلد ۱۰، شماره ۲، صفحات ۱۵۷-۱۶۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effect of Topical Petroleum Ether and Ethyl Acetate Fractions From Euphorbia milii on Imiquimod-induced Psoriasis-like Skin Inflammation in Mice |
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| چکیده انگلیسی مقاله |
Background: Psoriasis is a chronic, untreatable and disabling disease. In this research, we investigated the pharmacological properties of Euphorbia milii petroleum ether and ethyl acetate in a psoriasis mouse model.
Methods: Thirty-one albino mice were used in this study. They were divided into five groups: group I, healthy animals; group II, inducer group with imiquimod 12.5 mg (5% cream); and groups III, IV and V were imiquimod-induced and then treated with clobetasol 0.05% in group III, E. milii petroleum ether fraction in group IV and E. milii ethyl acetate fraction in group V. Immunohistochemistry for interleukin-17 (IL-17), vascular endothelial growth factor and transforming growth factor-beta, as well as histopathology were done on the mice skin.
Results: E. milii petroleum ether group showed a significant decrease in skin immunohistochemistry of IL-17, transforming growth factor-beta, and other histopathology parameters, while ethyl acetate fraction showed a significant reduction in vascular endothelial growth factor and other histopathology parameters
Conclusion: E. milii petroleum ether and ethyl acetate fractions may have a role in psoriasis treatment in a mice model. |
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| کلیدواژه‌های انگلیسی مقاله |
Euphorbia milii, Interleukin-17 (IL-17), Imiquimod, Psoriasis, Vascular endothelial growth factor (VEGF) |
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| نویسندگان مقاله |
| Mohammed Fareed Hameed
Department of Pharmacology and Toxicology, College of Pharmacy, Al-Nahrain University, Baghdad, Iraq.
| Ayah F. Al-Qrimli
Department of Pharmacognosy, College of Pharmacy, Al-Nahrain University, Baghdad, Iraq.
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| نشانی اینترنتی |
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-1295-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
فارماکولوژی |
| نوع مقاله منتشر شده |
پژوهشی |
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