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Immunoregulation، جلد ۶، شماره ۱، صفحات ۳۹-۵۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Therapeutic Challenges in Sulfur Mustard Induced Pulmonary Complications and Mesenchymal Stem Cells |
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| چکیده انگلیسی مقاله |
Sulfur mustard (SM), an alkylating chemical agent, targets several organs, particularly the respiratory system, and results in early and late toxic effects. Currently, there is a considerable lack of adequate medical countermeasures for SM-associated lung injury. Mesenchymal stem cells (MSCs) are characterized by their self-renewal properties and differentiation capacity into multiple cell lineages. These features provide MSCs with the unique ability to engraft into injured tissues and exert immunomodulatory and tissue-repairing effects. Recent congruent findings on the usefulness of MSCs in the context of SM-induced pulmonary injury have raised the promise of their therapeutic use; however, their potential protective mechanisms are still unknown. A better understanding of the therapeutic mechanism of MSCs involved in SM-pulmonary injury would help figure out new target options. Accordingly, this study discusses the opportunities and therapeutic mechanisms of MSCs in SM poisoning. Recent advances in the treatment of SM-induced lung injury and the therapeutic mechanisms of MSCs as possible new treatments are highlighted. The PubMed and Scopus databases for published studies on the therapeutic approach of SM-induced lung manifestations were searched with a focus on the therapeutic mechanisms of MSCs. |
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| کلیدواژه‌های انگلیسی مقاله |
Sulfur Mustard,
Mesenchymal stem cell,
Inflammation,
Lung injury,
Oxidative stress |
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| نویسندگان مقاله |
Somaye Sadeghi |
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
Ali Mohammad Mohseni Majd |
Immunoregulation Research Center, Shahed University, Tehran, Iran.
Nariman Mosaffa |
Department of Immunology, Faculty of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Tooba Ghazanfari |
Immunoregulation Research Center, Shahed University, Tehran, Iran.
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| نشانی اینترنتی |
https://immunoreg.shahed.ac.ir/article_4529_3f08008dba0e110743552e2296d2291e.pdf |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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