| چکیده انگلیسی مقاله |
Background: Although peripheral nerve injury is not life-threatening, it causes significant disability. Following these damages, ischemia and inflammatory processes occur, resulting in neurological dysfunction. Several medications have been explored in order to alleviate the symptoms of peripheral nerve injury.
Objectives: This study aimed to investigate how crocin and azithromycin affected sciatic nerve crush injuries in rats.
Methods: Five groups were established using 40 adult male rats: Control, Lesion, Azithromycin (AZ), Crocin (CR), and AZ+CR. Except for the control group, sciatic nerve injury was surgically induced in every other group. For seven days, azithromycin and crocin were administered. Following the behavioral evaluations, sections of sciatic nerve were stained for immunohistochemical , histological and morphometric assessment.
Results:, The efficacy of crocin treatment was more pronounced in comparison to that of azithromycin (p≤0.001). Crocin was found to be less efficacious than combination therapy involving AZ and CR, as determined by Sciatic functional index (SFI) (p≤ 0.001), hot plate (p≤0.001), and immunohistochemical analysis (p≤0.001). In the remaining evaluations, no significant difference existed between the AZ+CR and CR groups (p> 0.05).
Conclusion: This study found that both azithromycin and crocin significantly improved the recovery of sciatic nerve injuries in rats, with crocin being more effective. The combination of azithromycin and crocin showed even greater benefits in some assessments compared to crocin alone, although no significant differences were observed in other evaluations. These findings suggest that crocin is a promising treatment for peripheral nerve injury and that combination therapy may enhance certain recovery aspects. |
| کلیدواژههای انگلیسی مقاله |
Sciatic nerve injury, Azithromycin, Crocin, Rats, Saffron, Peripheral nerve injury |
| نویسندگان مقاله |
| Mohammad Ebrahim Abbaszadeh
Department of Anatomical Sciences, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
| Bagher Pourheydar
Department of Anatomical Sciences, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
| Gholamhossein Farjah
Department of Anatomical Sciences, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
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