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Immunoregulation، جلد ۶، شماره ۲، صفحات ۱۴۷-۱۵۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Investigating Local Delivery of Mesenchymal Stromal Cell Extracellular Vesicles for Treatment-resistant Periodontitis: A Hypothesis |
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| چکیده انگلیسی مقاله |
Background: One of the main reasons for tooth loss and functional incompatibility of dentition is periodontitis which is a multi-factorial disease. Among the main reasons for periodontitis is inflammation.
Hypothesis: Some keystone bacteria, such as Prophyromonas gingivalis with a notable number of virulence factors could activate and modify inflammatory pathways in gingiva. A well-established therapy for this disease is topical antibiotics; however, these treatments have side effects and could promote antibiotic-resistant infections as well. Such antibiotic-resistant infections are a group of periodontitis with a severely complicated treatment approach that could fail. Thus, new strategies need to be developed for treatment-resistant (antibiotic-resistant) periodontitis. In the past decades, many randomized controlled clinical trials have shown that mesenchymal stromal cells (MSCs) could treat inflammatory-dependent diseases or disorders. In addition to MSCs, the anti-inflammatory effects of their extracellular vesicles (EVs) have also been studied in the clinic.
Results: Considering the anti-inflammatory potential of MSCs-derived EVs, it could be hypothesized that local delivery of these EVs could be an effective method for periodontal treatment due to the accessible location of the periodontium.
Conclusion: This study suggests further in vivo studies and randomized clinical trials on the potential effects of MSCs-derived EVs on periodontal disease treatment. |
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| کلیدواژههای انگلیسی مقاله |
Periodontitis,
Mesenchymal stromal cells (MSCs),
Extracellular vesicles (EVs),
Drug delivery system |
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| نویسندگان مقاله |
Koosha Farshadianpour |
Department of Periodontics, Faculty of Dentistry, Guilan University of Medical Sciences, Rasht, Iran.
Kiarash Kiani |
Faculty of Dentistry, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
Mona Saligheh Rad |
Faculty of Dentistry, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
Maryam Norooznezhad |
Department of Radiology, Faculty of Dentistry, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
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| نشانی اینترنتی |
https://immunoreg.shahed.ac.ir/article_4575_2817b7648777fd59f07aacaba1328782.pdf |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
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