| چکیده انگلیسی مقاله |
Anti-IgLON5 is a neurological condition with neurodegenerative and autoimmune etiology. A 64-year-old man with a 2-year history of aplastic anemia presented with symmetrical parkinsonism, fluctuating consciousness, supranuclear gaze palsy, mild fasciculation, and muscular atrophy. He had disturbances in his sleep cycle and brain MRI. CSF analysis was positive for the IgLON5 antibody. We initiated immunotherapy with high-dose methylprednisolone, intravenous immunoglobulin, and rituximab. The patient showed a mild to moderate response to treatment. We reviewed 29 published case reports regarding anti-Iglon-5 and examined the clinical manifestation. None of the cases showed aplastic anemia, which was the main presentation in our case. All of the patients experienced sleep disturbances, while other symptoms were heterogeneous. Anti-Iglon-5 is usually diagnosed late, leading to a weak prognosis. This study helped us establish a better understanding of the correlation between anti- Iglon5 disease and other autoimmune disorders like anemia. |
| نویسندگان مقاله |
| Abbas Tafakhori
Deparment of Neurology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
| Seyyed Reza Ebadi
Deparment of Neurology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
| Hamed Amirifard
Deparment of Neurology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
| Saeed Karima
Deparment of Biochemistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| Arian Hasani
Tehran Heart center, Tehran University of Medical Sciences, Tehran, Iran
| Nazanin Esmaeili
InPedia association, Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
|