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Journal of Pediatrics Review، جلد ۱۲، شماره ۳، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Urinary Calprotectin as a Biomarker in the Early Diagnosis of Pediatric Acute Kidney Injury: A Systematic Review and Meta-Analysis |
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| چکیده انگلیسی مقاله |
Background: The available evidence suggests that urinary calprotectin may be a potential biomarker in distinguishing between intrinsic acute kidney injury (AKI) and prerenal AKI. The aim of this study was to determine the diagnostic value of calprotectin in identifying pediatric acute renal impairment.
Methods: A search of the Medline, Embase, Scopus, and Web of Science electronic databases was conducted in April 27, 2024. Diagnostic studies conducted on the value of urinary calprotectin in AKI were included. Two independent reviewers assessed the search records and any disagreements were resolved by discussion. Risk of bias was assessed using quality assessment of diagnostic accuracy studies (QUADAS-2) guidelines. The performance of urinary calprotectin in diagnosis of AKI and its discriminatory ability between intrinsic and prerenal AKI, was assessed by calculating pooled standardized mean difference (SMD) and 95% confidence interval (CI), sensitivity, specificity and area under the curve (AUC).
Results: Seven studies were included. Mean urinary levels of calprotectin in AKI were significantly higher than non-AKI group (SMD = 0.73; 95% CI: 0.50 to 0.97; I2 = 0.00%). It was also found that the mean urinary level of calprotectin in pediatric with intrinsic AKI was significantly higher than pre-renal AKI (SMD = 0.76; 95% CI: 0.48 to 1.05; 95% CI: 0.00%). Urinary calprotectin exhibited a sensitivity 0.937 (95% CI: 0.829, 0.978) and specificity of 0.252 (95% CI: 0.126, 0.442) for distinguishing intrinsic than prerenal AKI . In addition, the AUC of urinary calprotectin in differentiating intrinsic AKI from pre-renal AKI was equal to 0.691 (95% CI: 0.541 to 0.809).
Conclusion: Urinary calprotectin has fair screening performance characteristics for differentiating intrinsic from prerenal AKI in children. However, the low specificity calls for additional diagnostic testing in positive results. |
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| کلیدواژه‌های انگلیسی مقاله |
Biomarker, Urinary level, Diagnostic performance, Acute kidney injury |
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| نویسندگان مقاله |
| Mohammadmehdi Hasheminejad
Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
| Ayda Dadras
Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
| Amirmohammad Toloui
Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
| Behnaz Bazargani
Pediatrics Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
| Neamatollah Ataei
Pediatrics Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
| Hamzah Adel Ramawad
Department of Emergency Medicine, NYC Health & Hospitals, Coney Island, New York.
| Mahmoud Yousefifard
Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
| Mostafa Hosseini
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical, Tehran, Iran.
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| نشانی اینترنتی |
http://jpr.mazums.ac.ir/browse.php?a_code=A-10-1169-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Nephrology |
| نوع مقاله منتشر شده |
Meta-analysis Review |
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