| چکیده انگلیسی مقاله |
Background: During the COVID-19 pandemic, excessive use of antibiotics to manage co-infections and reduce mortality rates may have contributed to the increase in antimicrobial resistance.
Objectives: This research was conducted to evaluate the antibiotic resistance patterns of multidrug-resistant Pseudomonas aeruginosa strains in the era of the COVID-19 pandemic in North Iran.
Methods: Between May 2022 and June 2023, cross-sectional research was conducted at four teaching hospitals in Sari, Iran. The macro dilution broth technique was employed to determine the minimum inhibitory concentration (MIC). All isolates were screened by Multiplex Polymerase Chain Reaction (PCR) method for AmpC, blaCTX, blaSHV, blaSIM, blaSPM, blaIMP, and also virulence genes including TOXA and ExoS.
Results: The results determined the antibiotics Co-amoxiclav and Gentamicin showed the least activity in terms of MIC50 values. Meropenem had the most potent activity based on GM MIC values. Multiplex Polymerase Chain Reaction method showed all isolates had the ExoS toxin gene, while the ExoA gene was not detected. The frequency of resistance genes observed were blaSHV (91.3%), blaCTX-M (76%), AmpC (91.3%), and blaIMP (95.2%). The blaSPM and blaSIM genes were not distinguished.
Conclusion: In this research, Piperacillin/tazobactam and Meropenem recommended for treating multi-drug-resistant Pseudomonas aeruginosa infections. |
| نویسندگان مقاله |
| Fatemeh Hosseinzadeh
Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
| Golnar Rahimzadeh
Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
| Seyedeh Mahsa Salehpour
Students Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
| Shaghayegh Rezai
Department of Medical Microbiology and virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
| Reza Valadan
Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran
| Laleh Vahedi
Department of Pathology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
| Somayeh Sheidaei
Department of Pathology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
| Faezeh Sadat Movahedi
Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
| Raha Rezai
Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
| Mohammad Sadegh Rezai
Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
| Fatemeh Ahangarkani
Antimicrobial Resistance Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
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