|
|
Basic and Clinical Neuroscience، جلد ۱۵، شماره ۵، صفحات ۰-۰
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Evidence for Immune Dysregulation in Migraine Pathophysiology: A Preliminary Meta-analysis of Regulatory T-cell Reduction in Migraine Patients |
|
| چکیده انگلیسی مقاله |
Background & Objectives
The etiology of migraine is not fully understood, but there is ongoing debate about the potential role of immune dysfunction in migraine pathophysiology. Some clinical studies have shown a reduction in CD4+CD25+ Regulatory T cells (Treg) in migraine patients compared to healthy volunteers. However, these studies have not been systematically analyzed. The primary objective of this study is to conduct a systematic review of Treg level changes in migraine patients.
Methods
A detailed literature search was conducted on PubMed, Scopus, Embase, ProQuest, Cochrane review, Clinical trials, Academic thesis, American Academy of Neurology resources and Google Scholar databases from 2010 to 2023. Studies that were appropriately designed to quantify Treg levels in migraine patients were included in this meta-analysis.
Results
Out of 17 studies initially reviewed, only 4 studies with a total of 121 migraine patients were included for analysis. The meta-analysis revealed a statistically significant reduction in Treg levels in migraine patients compared to healthy volunteers (Z=1.21; p=0.23).
Conclusion
The observation of lower levels of Treg in migraine patients, compared to healthy volunteers, provides support for the theory that migraine may be an autoimmune disorder. However, to fully understand the role of immune dysregulation in migraine pathogenesis, additional clinical data is required. This is the first meta-analysis of Treg levels in the context of migraine research, adding a significant contribution to the existing literature on the topic. |
|
| کلیدواژه‌های انگلیسی مقاله |
Migraine, CD4+ T cells, Regulatory T cells, CD4+CD25+ Regulatory T cells, FOXP3, Autoimmunity |
|
| نویسندگان مقاله |
| Murugesan Arumugam
Department of Pharmacology, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research
| Subalakshmi Sugumar
Department of Pharmacology, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research
| Saman Shah
Department of Pathology, Hind Institute of Medical Sciences, Barabanki 225003, Uttar Pradesh, India
| Philo Hazeena
Sri Ramachandra medical college, Sri Ramachandra Institute of Higher Education and Research
| Deepa Avadhani
Sri Ramachandra medical college, Sri Ramachandra Institute of Higher Education and Research
| Pavithra Murugan
Department of Pharmacology, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research
|
|
| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-2447-2&slc_lang=en&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cellular and molecular Neuroscience |
| نوع مقاله منتشر شده |
Review |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|