Background& Aim: Breast cancer is one of the most common cancers and the main cause of death in women. One of the mechanisms of cancer cells for the lack of access to the immune system is the production of compounds suppressing immune responses such as interleukin-10. On the other hand, vascular endothelial growth factor by binding to its receptors on the surface of endothelial cells plays an important role in vascular permeability and tumor vascularity. In this study, the expression of interleukin-10 and vascular endothelial growth factor in breast tumor tissue was investigated in an experimental tumor model.