Background: The present study was conducted with the aim of investigating the effectiveness of schema therapy on marital satisfaction and mental health of women undergoing hysterectomy surgery. 

  Methods: This research was applied in terms of objective and quantitative research, and in terms of data collection method it was semi-experimental research with two experimental and control groups with pre-test and post-test. The statistical population consisted of all women aged 30 to 50 who underwent hysterectomy surgery in 1402 in Yazd city. In this study, 30 eligible subjects were selected by available method and the participants were randomly divided into two experimental and control groups (15 people in each group). For the experimental group, the treatment plan was implemented in 10 sessions of 50 minutes. Goldberg's mental health questionnaire and Inrich's marital satisfaction questionnaire were used to measure the research variables. Results: The findings from the analysis of covariance test showed the use of schema therapy approach increased the marital satisfaction and mental health of women undergoing hysterectomy surgery pscinificantly (p≤0.001). 

  Conclusion: Therefore, the use of schema therapy sessions in medical centers for people who underwent hysterectomy surgery is suggested to reduce marital problems.