| چکیده انگلیسی مقاله |
Introduction: Intracranial pressure (ICP) elevation leading to cerebral edema is a critical condition that should be identified and treated immediately. In this study, we systematically reviewed the articles investigating the role of hypertonic sodium lactate (HSL) in patients with traumatic brain injury.
Methods: PubMed, Scopus, Embase, and Web of Science were searched to find published articles on the effects of HSL on ICP in patients with a traumatic brain injury until December 2020. Animal studies, case reports, and studies, including patients with liver and renal failure, cardiac dysfunction, or hypovolemic shock, were excluded. The Newcastle-Ottawa scale checklist was used to assess the methodological quality of eligible articles. Information obtained was classified based on the following criteria: demographic data, methods, intervention, and outcomes.
Results: Our initial search with the predefined search strategy proceeded with 113 studies. Finally, 7 studies were eligible for systematic review, and 3 of them were eligible for meta-analysis. A random meta-analysis of 3 articles comparing ICP before and after the infusion of HSL showed a reduced ICP following the use of HSL in traumatic brain injuries (P=0.015).
Conclusion: Our study demonstrated the undeniable role of hypertonic sodium lactate in managing increased ICP in patients with brain injury. Nevertheless, conducting more clinical studies to assess the possible side effects of HSL seems crucial. |
| نویسندگان مقاله |
| Reza Mosaed
Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
| Arash Akhavan Rezayat
Health policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
| Behnaz Rohani
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Aida Ayati Afin
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Farhad Najmeddin
Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
| Shahideh Amini
Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
| Maryam Taghizadeh-Ghehi
Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran.
| Mohamad Afshar Ardalan
The instructor of internal medicine, Faculty of medicine, Aja university of medical sciences, Tehran, Iran.
| Atabak Najafi
Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
| Mojtaba Mojtahedzadeh
Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
|