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Journal of Research in Orthopedic Science، جلد ۱۰، شماره ۳، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Exploring the Role of Wnt Signaling Pathway in Orthopedic Health and Disease: Mini-Review |
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| چکیده انگلیسی مقاله |
The intricate orchestration of cell types and developmental processes in multicellular organisms hinges upon signaling pathways like Wnt, which plays pivotal roles in both embryonic development and adult tissue homeostasis. Over the past four decades, significant strides have been made in elucidating the complexities of the Wnt signaling pathway and its diverse physiological functions. Notably, Wnt signaling has emerged as a crucial regulator in orthopedic contexts, particularly in fracture healing and osteoarthritis. This review delves into the intricate involvement of the Wnt pathway in these orthopedic conditions, exploring its impact on bone formation, chondrogenesis, and joint pathologies. Moreover, it examines the therapeutic potential of targeting Wnt signaling in the treatment of osteoporosis, highlighting the promising avenues opened by advancements in understanding rare bone disorders such as sclerosteosis and van Buchem disease. Through elucidating the multifaceted roles of Wnt signaling in orthopedic health and disease, this review offers insights into potential therapeutic strategies for enhancing fracture healing, mitigating osteoarthritis progression, and addressing bone-related disorders. |
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| کلیدواژه‌های انگلیسی مقاله |
Wnt signaling pathway, Orthopedic conditions, Fracture healing, Osteoarthritis, Osteoporosis, Sclerosteosis, Bone formation, Chondrogenesis, Therapeutic targeting |
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| نویسندگان مقاله |
| Morteza Nakhaei Amroodi
Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Department of Orthopedic, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
| Khatere Mokhtari
Department of Cellular and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
| Mojtaba Baniasadi
Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Department of Orthopedic, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
| Saeedreza Amiri
Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Department of Orthopedic, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
| Mansour Karimi
Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Department of Orthopedic, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
| Pouria Tabrizian
Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Department of Orthopedic, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
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| نشانی اینترنتی |
http://jros.iums.ac.ir/browse.php?a_code=A-10-526-4&slc_lang=en&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
شانه / آرنج |
| نوع مقاله منتشر شده |
مروری |
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