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، جلد ۱۹، شماره ۱، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Comparative Analyses of Serum Toxic Heavy Metal Ions in Opium Addicts and Healthy Controls |
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| چکیده انگلیسی مقاله |
Background: Opium consumption and its adverse effects are believed to be a major public health problem particularly in Iran, Afghanistan and other nations in the Middle East. Exposure to toxic heavy metals has increased in people who are addicted to opium due to its contamination with various toxic heavy metals. This study aimed to investigate the levels of trace elements in the sera of opium users versus nonuser individuals.
Methods: This cross sectional study compared a group of individuals with a history of opium use (n=54) with a group of non-opium users (n=70). We determined the serum levels of select toxic and essential elements, such as lead, mercury, thallium, nickel, chromium, cobalt, and copper, using inductively coupled plasma spectrometry (ICP).
Results: The serum levels of lead, chromium, mercury and copper were significantly higher in opium users compared to non-users. Principal component analysis and cluster analysis were applied for the apportionment and source identification of the metals in the serum samples of the two groups.
Conclusions: The study findings indicated that opium addiction adversely impacted the serum levels of the heavy metals and some essential elements in the addicts. The findings suggest the necessity for the assessment of heavy metals and trace elements in substance abusers. It might also be helpful in drawing strategies toward the prevention and treatment approaches by assessing various toxic elements in biological samples of opium dependents. |
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| کلیدواژه‌های انگلیسی مقاله |
Addiction, Chromium, Heavy metals, Lead, Mercury, Opium, Trace elements |
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| نویسندگان مقاله |
| Kiomars Sharafi
Research Center for Environmental Determinants of Health, Health Institute, Kermanshah University of Medical Sciences. Kermanshah, Iran
| Samaneh Nakhaee
Medical Toxicology and Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran
| Borhan Mansouri
Substance Abuse Prevention Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
| Bahareh Rahami
Substance Abuse Prevention Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
| Alireza Amirabadizadeh
Medical Toxicology and Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran
| Kamran Tavakol
Emeritus Professor, College of Medicine, Howard University, Washington, D.C., USA
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| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1297-1&slc_lang=en&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
پژوهشی |
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