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Caspian Journal of Neurological Sciences، جلد ۳، شماره ۸، صفحات ۳۹-۴۵
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| عنوان انگلیسی |
MTHFR rs1801133 Gene Polymorphism and Autism Susceptibility |
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| چکیده انگلیسی مقاله |
Background: It is believed that environmental and genetic factors may be responsible for autism. Methylenetetrahydrofolate reductase (MTHFR) and its gene polymorphisms have been shown to be implicated as risk factors in autism. Objectives: To analyze MTHFR C677T polymorphism (rs1801133) in autistic patients. Materials and Methods: This study was carried out in 2014 and 2015 in northern Iran. One hundred and seventy-one male autistic patients and 198 healthy males were included in this study. Autism was diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria. Each autism spectrum disorder (ASD) patient was also evaluated by the Childhood Autism Rating Scale (CARS). All participants were tested for C677T polymorphism by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Statistical analyzes were performed using MedCalc version 12.1 by the χ2 test and logistic regression model. A value of p< 0.05 was considered statistically significant. Results: The mean age±SD of case and control groups was 13.5±2.7 and 15.6±3.7 years. The mean±SD of CARS score was 36.2±1.7. The genotype frequencies of CC, TC, and TT in children with autism were 50.9%, 45.6%, and 3.5%, respectively, and in control group were 54.5%, 44.0%, and 1.5%, respectively (p>0.05). The allele frequencies of C and T in children with autism were 73.0% and 27.0%, and in control group were 76.0% and 24.0%, respectively (p>0.05). Conclusion: MTHFR C677T polymorphism is not associated with autism in a population in the north of Iran. |
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| نویسندگان مقاله |
مهسا delshadpour | mahsa delshadpour
department of biology, faculty of sciences, university of guilan, rasht, iran
سازمان اصلی تایید شده: دانشگاه گیلان (Guilan university)
فرهاد مشایخی | farhad mashayekhi
department of biology, faculty of sciences, university of guilan, rasht, iran; mashayekhi@guilan.ac.ir
سازمان اصلی تایید شده: دانشگاه گیلان (Guilan university)
الهام بیدآبادی | elham bidabadi
faculty of medicine, guilan university of medical sciences, rasht, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)
زیور صالحی | zivar salehi
department of biology, faculty of sciences, university of guilan, rasht, iran
سازمان اصلی تایید شده: دانشگاه گیلان (Guilan university)
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| نشانی اینترنتی |
http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-64&slc_lang=fa&sid=en |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/1782/article-1782-347270.pdf |
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| زبان مقاله منتشر شده |
en |
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