| چکیده انگلیسی مقاله |
Background: Nimesulide, a widely used non-steroidal anti-inflammatory drug (NSAID), is prescribed for pain relief, osteoarthritis, and dysmenorrhea. Variations in manufacturing processes can result in quality differences across brands, potentially affecting efficacy and safety. This study aims to assess the pharmacopeial quality control parameters and price variation of ten brands of Nimesulide tablets available in the Nepalese market.
Methods: Ten different brands of Nimesulide 100 mg tablets (five Nepalese and five Indian) were randomly selected. Quality control tests, including weight variation, hardness, friability, disintegration, dissolution, and drug content assay, were performed following British Pharmacopoeia standards. Price variation was also assessed.
Results: All brands met the pharmacopeial standards for weight variation, hardness, friability, disintegration, dissolution, and drug content. Minor variations were observed in disintegration time and dissolution rates. Indian brands were relatively more expensive than Nepalese brands.
Conclusion: meropenem and cephalosporins/siderophore cephalosporins have similar effectiveness as therapy for gram-negative infections in HAP . |