| چکیده انگلیسی مقاله |
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is an infrequent yet severe idiosyncratic reaction to drugs, characterized by a diverse range of systemic manifestations and a mortality rate of 10% to 20%. Commonly associated with anticonvulsant drugs and sulfonamides, DRESS syndrome poses diagnostic challenges due to its variable presentation. This study presents a unique case of lamotrigine-induced DRESS associated with acalculous cholecystitis, an unprecedented manifestation. The patient, initially treated with levetiracetam and lamotrigine for generalized epilepsy, experienced a delayed onset of symptoms, with a European registry of severe cutaneous adverse reactions (RegiSCAR score of 7, confirming the diagnosis. Reactivation of Epstein-Barr virus was detected, suggesting a potential link between herpesvirus reactivation and DRESS pathogenesis. The case underscores the importance of careful monitoring and consideration of atypical organ involvement in DRESS diagnosis. Lamotrigine withdrawal resulted in rapid clinical resolution, allowing for a cautious transition to an alternative anti-epileptic medication which is valproate. This case contributes to the evolving understanding of DRESS syndrome, emphasizing the need for a comprehensive diagnostic approach in complex medication regimens. |
| نویسندگان مقاله |
Safa Akeel Al-Hasan |
Department of Surgery, Faculty of Medicine, Kufa University, Kufa, Iraq.
Ali Abdulkareem Al-Fahham |
Department of Ophthalmology, Najaf Teaching Hospital, Najaf, Iraq.
Samih Akeel Al-hasan |
Department of Surgery, Faculty of Medicine, Jabir Ibn Hayyan Medical University, Najaf, Iraq.
Baraa Akeel Al-Hasan |
Department of Medical Laboratory Technology, College of Medical Technology, The Islamic University, Najaf, Iraq.
Fatma Akeel Al-Hasan |
Department of pharmacy, Najaf Teaching Hospital, Najaf, Iraq.
Ahmed Maki Radeef |
Department of Anesthesia Techniques, College of Health and Medical Techniques, Al-Mustaqbal University, Babylon, Iraq.
Haider Abbas Hadi Al-Mhanaa |
College of Nursing, Al-Mustaqbal University, Babylon, Iraq.
Ali Salah Wadday |
Department of Animal Husbandry, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary.
Ghadeer Sabah Bustani |
Department of Medical Laboratory Technology, College of Medical Technology, The Islamic University, Najaf, Iraq.
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