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Pharmaceutical and Biomedical Research، جلد ۱۱، شماره ۱، صفحات ۴۹-۶۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Formulation and Assessment of Drug Release and Stability of New Antipsoriatic Emulgel |
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| چکیده انگلیسی مقاله |
Background: The objective of the present study was to formulate a new antipsoriatic emulgel from Aloe sinkatana extract, evaluate the formulations, and select an optimized formulation through in vitro drug release and drug content studies. A. sinkatana plant is a potent antipsoriatic agent traditionally used to treat psoriasis. The development of a dermal drug delivery system can overcome these side effects.
Methods: A 23 factorial design was selected to formulate A. sinkatana emulgel. The prepared emulgel was evaluated for general appearance, pH, viscosity, drug content, in vitro drug release, kinetics, and stability.
Results: Optimized formulation F3 showed the highest drug content and best in vitro drug release. The stability study for the optimized formulation was carried out at 25°C/60% relative humidity (RH), 30°C/65% RH, and 40°C/75% RH for 3 months, and the emulgel was found to be stable concerning the physical appearance, PH, phase separation, drug content, and microbial growth.
Conclusion: The study revolved around the formulation of emulgel containing A. sinkatana extract for dermal delivery of the drug. It was finally concluded that the emulgel formula F3 was the most promising topical herbal emulgel. |
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| کلیدواژه‌های انگلیسی مقاله |
Aloe sinkatana, Anti-psoriatic, Emulgel, Factorial design, Formulation |
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| نویسندگان مقاله |
| Azza Dawoud Hussien Dawoud
Department of Drug Formulation, Medicinal and Aromatic Plants & Traditional Medicine Research Institute, National Center of Research, Khartum, Sudan.
| Mohammed Abdalbagi
Department of Microbiology & Parasitology, Medicinal and Aromatic Plants & Traditional Medicine Research Institute, National Center of Research, Khartum, Sudan.
| Mohamed El Hassan Shayoub
Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.
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| نشانی اینترنتی |
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-1362-3&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
فارماسیوتیکس |
| نوع مقاله منتشر شده |
پژوهشی |
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