|
|
Iranian Journal of Veterinary Medicine، جلد ۲۰، شماره ۱، صفحات ۳۵-۴۲
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژههای فارسی مقاله |
|
|
| عنوان انگلیسی |
Characterization of Serum Concentration of CD8, CD4, Interfron-γ, and Interleukin-4 in 4T1 Tumor Inoculated Mouse Model |
|
| چکیده انگلیسی مقاله |
Background: Malignancies in domesticated animals, including cats and dogs, present significant health challenges. The 4T1 tumor-inoculated mouse model is pivotal for studying tumor biology and therapeutic strategies.
Objectives: This study aimed to characterize immune system alterations in the 4T1 tumor-inoculated mouse model by assessing serum concentrations of CD4 and CD8 antigens, along with cytokines interferon (IFN)-γ and interleukin (IL)-4.
Methods: BALB/c female mice were subcutaneously inoculated with 4T1 cells. Serum levels of CD4, CD8, IFN-γ, and IL-4 were quantified using ELISA, and histopathological analysis was performed to confirm tumorgenesis.
Results: Tumor-bearing mice exhibited significantly elevated CD8 levels (mean: 7.2613 ng/mL) compared to healthy controls (mean: 1.9749 ng/mL), whereas CD4 levels were lower in tumor-bearing mice (mean: 2.7632 ng/mL) compared to controls (mean: 4.8677 ng/mL). IFN-γ levels were reduced (mean: 10.95238 vs 22.85714 pg/mL), while IL-4 levels were increased (mean: 27.76942 vs 10.85452 pg/mL).
Conclusion: The 4T1 tumor model induces significant immune alterations, highlighting its utility for studying tumor immune evasion mechanisms and advancing immunotherapy strategies. |
|
| کلیدواژههای انگلیسی مقاله |
Animals,cancer,Cytokines,immune response,mouse model |
|
| نویسندگان مقاله |
Ghazale Vazifehdoust |
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Shahram Jamshidi |
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Gholamreza Nikbakht |
Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Mohammad Taheri |
Dr. Rastegar Laboratories, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Mahya Lalepoor |
Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
|
|
| نشانی اینترنتی |
https://ijvm.ut.ac.ir/article_101876_a6034bb7f4c48ef40f65d536f4d1a9d6.pdf |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
|
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|