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Basic and Clinical Neuroscience، جلد ۸، شماره ۲، صفحات ۱۲۱-۱۲۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Transient Inactivation of Shell Part of Nucleus Accumbens Inhibits and Exacerbates Stress-Induced Metabolic Alterations in Wistar Rats |
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| چکیده انگلیسی مقاله |
Introduction: The role of different parts of the extended amygdala in metabolic signs of stress is not well understood. In the present study, we decided to evaluate the impact of the shell part of nucleus accumbens (NAc) on metabolic disturbance induced by electro foot shock stress using transient inactivation method in the rat. Methods: Male Wistar rats (W: 230-250 g) were canuulated unilaterally in the shell part of nucleus accumbens and left one week for recovery. Five minutes before each stress session, the animals either received sterile saline (0.25 µl/side) (control) or lidocaine 2% (0.25 µl/side) (experiment). Blood samples were taken from rats’ retro-orbital sinus for plasma corticosterone measurements. In addition, animals’ weight gain, food and water intake, locomotor activity, and rearing were recorded. Results: Stress reduced weight gain and food intake, increased water intake and plasma corticosterone level, and reduces locomotor activity and rearing. Transient inactivation of the right side of the NAc inhibits the stress effect on weight gain, water intake and plasma corticosterone level, but not food intake. However, when the left side of the NAc was inactivated, only weight gain was affected and other parameters were not differing from stress group. Even thought, the plasma corticosterone level was elevated. Conclusion: In conclusion, our data indicated that right side of shell part of NAc transient inactivation leads to reduction in metabolic signs of stress but left side of shell part of the NAc inactivation even exacerbates stress signs. |
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| کلیدواژههای انگلیسی مقاله |
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| نویسندگان مقاله |
مینا رنجبران | mina ranjbaran
neuroscience research center, baqiyatallah a.s. university of medical sciences, tehran, iran.
حسن آقایی | hassan aghaei
neuroscience research center, baqiyatallah a.s. university of medical sciences, tehran, iran.
وحدت حاجی حسینلو | vahdat hajihoseinlou
neuroscience research center, baqiyatallah a.s. university of medical sciences, tehran, iran.
هدایت صحرایی | hedayat sahraei
neuroscience research center, baqiyatallah university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)
کتایون رنجبران | katayoon ranjbaran
farhangian university, branch shahid bahonar, hamedan, iran
سازمان اصلی تایید شده: دانشگاه فرهنگیان (Farhangian university)
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-15-9&slc_lang=en&sid=en |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/198/article-198-383162.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
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