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Immunoregulation، جلد ۱، شماره ۱، صفحات ۱-۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
TNF-α production is modulated by Aloe vera gel extract and its fractions in Candida albicans infected macrophages |
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| چکیده انگلیسی مقاله |
Background: Aloes have been used as medicinal plants for centuries. The immunomodulatory effect of Aloe vera has previouslybeen shown. Meanwhile, TNF-α, as an inflammatory cytokine, plays an essential role in defense against invading pathogen.Objectives: In the present study, the effects of A. vera extract gel and its fractions were investigated on the TNF-α production bymacrophages against Candida albicans as an opportunistic microorganism in humans.Materials and methods: TNF-α was measured using Enzyme-Linked Immunosorbent Assay according to the instructions of themanufacturer (Biosource, Switzerland).Results: The results showed that TNF-α level was increased by A. vera gel extract and some isolated fractions dose dependently.The A. vera gel extract in dilutions of 1:2, 1:5, 1:10 and 1:50 significantly increased the production of TNF-α. Likewise, R100 andR30 fractions of A. vera caused significant increase in TNF-α production. However, R10 and R5 fractions caused a reduction inTNF-α production as compared with that in control group.Conclusions: These results showed that A. vera gel extracts and its fractions induce both immunostimulating and immunosuprressiveeffects on the production of TNF-α against Candida albicans. The efficacy of immunomodulatory of this herb is dose-dependent |
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| کلیدواژههای انگلیسی مقاله |
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| نویسندگان مقاله |
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| نشانی اینترنتی |
http://immunoreg.shahed.ac.ir/article_481_e5bba74091dfd8a169a4298b46d2ba79.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2435/article-2435-416107.pdf |
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| زبان مقاله منتشر شده |
en |
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