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Iranian Rehabilitation Journal، جلد ۱۵، شماره ۲، صفحات ۵۴-۶۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Investigation of the Relationship between A Genetic Polymorphism in ACTN3 and Elite Sport Performance among Iranian Soccer Players |
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| چکیده انگلیسی مقاله |
Objectives: α-Actinin-3 (ACTN3) gene polymorphisms are considered to be the most important candidate genes for genetic predisposition to human athletic performance. Most of the activities in soccer such as jumping, striking the ball, and running are considered plyometric and explosive. Performance power during such activities depends on the strength of the muscles involved. Therefore, having high muscle strength is crucial for soccer players. The main purpose of the present study was to ascertain the association between ACTN3 R577X (rs1815739) polymorphism and sports athletism in Iranian elite male soccer players. Methods: In total, 90 top-level professional Iranian male soccer players and 200 non-athletic Iranian men from the general population participated in this case–control study. Exon 16 of ACTN3 was genotyped throughout polymerase chain retroaction (PCR) followed by Restriction Fragment Length Polymorphism (RFLP) using the restriction enzyme DdeI and direct sequencing. The genotypic and allelic frequencies of R577X polymorphism in athletes were compared to the frequencies in the general population (non-athletes). Results: The results showed that the percentage distributions of 577RR and 577RX genotypes (41% and 37%) were statistically significantly higher and lower, respectively, than those in controls (25% and 57%) (p< 0.001). However, no statistically significant difference was found between allelic frequencies (p=0.20). Discussions: Our findings showed a significant association between ACTN3 genotypes and elite sport performance among Iranian male soccer players, in agreement with several previous studies. |
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| نویسندگان مقاله |
عسل honarpour | asal honarpour
genetics research center, university of social welfare and rehabilitation sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم بهزیستی و توانبخشی (University of social welfare and rehabilitation sciences)
مرضیه محسنی | marziyeh mohseni
genetics research center, university of social welfare and rehabilitation sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم بهزیستی و توانبخشی (University of social welfare and rehabilitation sciences)
سیامک قویدل حاجی آقا | siyamak ghavidel haji agha
islamic azad university, tehran medical branch,tehran,iran,
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
شیوا ایرانی | shiva irani
department of biology, science and research branch, islamic azad university, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
حسین نجم آبادی | hossein najmabadi
genetics research center, university of social welfare and rehabilitation sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم بهزیستی و توانبخشی (University of social welfare and rehabilitation sciences)
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| نشانی اینترنتی |
http://irj.uswr.ac.ir/browse.php?a_code=A-10-602-1&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
ژنتیک |
| نوع مقاله منتشر شده |
پژوهشی |
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