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Auditory and Vestibular Research، جلد ۲۳، شماره ۶، صفحات ۴۵-۵۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Role of creatine in sensitivity and function of the auditory and vestibular system |
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| چکیده انگلیسی مقاله |
Background and Aim: Creatine plays an important role in the regulation of cellular energy in high energy demand organs such as the inner ear. It is also believed to play a protective role. This article reviewed the mechanisms and effects of creatine on the auditory and vestibular systems. Recent Findings: Creatine transporters and creatine kinase enzymes are involved in converting creatine to creatine phosphate. Phosphate is a fuel cell available in the cochlear and vestibular hair cells and the protective cells, striavascularis, peripheral and central neural pathways to the auditory cortex. It provides essential ATP for auditory and vestibular system performance. Creatine kinase prevents cochlear damage by regulating the metabolism of energy in marginal layers of the striavascularis and preventing free radical production in stressful situations. It also plays an important role in vestibular compensation. Creatine kinase dysfunction leads to an increase in the threshold of auditory brainstem potentials and a reduction in vestibular performance. The use of creatine improves vestibular evoked myogenic potentials and neurologic symptoms. Conclusion: Creatine and creatine kinase protein is essential for normal hearing and balance function and sensitivity. Creatine kinase deficiency impairs the functioning of these two systems; however, creatine consumption may boost the sensitivity of the vestibular system and neurological performance. Effects of the creatine consumption on the auditory system have not yet been examined. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
وحید مرادی | vahid moradi
department of audiology, school of rehabilitation, tehran university of medical sciences, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
منصوره عادل قهرمان | mansoureh adel ghahraman
department of audiology, faculty of rehabilitation sciences, iran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
اکرم پوربخت | akram pourbakht
department of physiotherapy, school of rehabilitation, tehran university of medical sciences, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
صوفیا نقدی | soufia naghdi
biostatistics, school of rehabilitation, tehran university of medical sciences, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
شهره جلایی | shohreh jalaie
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| نشانی اینترنتی |
http://avr.tums.ac.ir/index.php/avr/article/view/204 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Review Article(s) |
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