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Anatomical Sciences Journal، جلد ۱۲، شماره ۴، صفحات ۱۷۱-۱۷۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Toxic Effects of Cisplatin on Hepatocytes and Liver Enzymes of Rats |
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| چکیده انگلیسی مقاله |
Introduction: Cisplatin is an antineoplastic drug, which is widely used for the treatment of solid tumors. However, its clinical usage is limited because of its side effects such as hepatotoxicity. This study aimed to identify toxic effects of cisplatin on hepatocytes of rats. Methods: A total of 45 adult Sprague Dawley rats weighing 200±30 g were randomly divided into experimental (n=30) and control (n=15) groups. Rats of experimental groups were divided into 2 subgroups; subgroup 1 received 2 consecutive 2.5mg/kg dose of cisplatin, intraperitoneally in the beginning of first and fifth weeks of the study. Subgroup 2 also received 2 consecutive 5mg/kg dose of cisplatin in the same manner of subgroup 1. After 8 weeks, rats of both groups were anesthetized and killed. Then, their blood and tissue samples were taken. Prepared sections were stained by HE method. Collected data from microscopic slides and blood samples were analyzed by SPSS using analysis of variance (ANOVA) and Tukey test. Results: Statistical analysis showed significant differences in the activity of enzymes (ALT, AST, ALP) between control and experimental groups (P< 0.001). Analysis of sinusoidal diameter also showed a significant difference between studied groups (P< 0.001) too. Conclusion: Cisplatin disorganizes the architecture of hepatic lobules and increases sinusoidal diameter in rat liver. |
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| کلیدواژههای انگلیسی مقاله |
Cisplatin, Liver, Enzymes, Sinusoidal diameter, Rat |
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| نویسندگان مقاله |
محسن میر | mohsen mir
zahedan university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)
محمدرضا عرب | mohammad reza arab
department of anatomy, school of medicine, zahedan university of medical sciences, zahedan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)
محمدرضا شهرکی | mohamad reza shahraki
zahedan university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)
محمد علی مشهدی | mohammad ali mashhadi
zahedan university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)
مسعود شهرکی سالار | masood shahraki salar
zahedan university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)
فریدون سرگلزایی اول | fereydoon sargolzai aval
zahedan university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)
محمد حسن کریم فر | mohammad hassan karimfar
zahedan university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)
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| نشانی اینترنتی |
http://www.anatomyjournal.ir/browse.php?a_code=A-10-119-1&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
1 |
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