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Anatomical Sciences Journal، جلد ۱۲، شماره ۴، صفحات ۱۹۱-۱۹۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
A Review Study: Using Stem Cells in Cartilage Regeneration and Tissue Engineering |
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| چکیده انگلیسی مقاله |
Articular cartilage, the load-bearing tissue of the joint, has limited repair and regeneration ability. The scarcity of treatment modalities for large chondral defects has motivated researchers to engineer cartilage tissue constructs that can meet the functional demands of this tissue in vivo. Cartilage tissue engineering requires 3 components: cells, scaffold, and environment. Owning to their easy isolation, expansion, and multilineage differentiation, adult stem cells, specifically multipotential mesenchymal stem cells, are considered the proper candidate for tissue engineering. Successful outcome of cell-based cartilage tissue engineering ultimately depends on the proper differentiation of stem cells into chondrocytes and assembly of the appropriate cartilaginous matrix to achieve the load-bearing capabilities of the natural articular cartilage. Furthermore, multiple parameters such as growth factors, signaling molecules, and physical conditions must be considered. Adult mesenchymal stem-cell-based tissue engineering is a promising technology for creating a transplantable cartilage replacement to improve joint function. |
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| کلیدواژههای انگلیسی مقاله |
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| نویسندگان مقاله |
رضا سامانی پور | reza samanipour
department of nuclear engineering and science, school of basic engineering, islamic azad university of najafabad, isfahan, iran.
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی نجف آباد (Islamic azad university of najafabad)
حسین صالحی رزوه | hossein salehi rozveh
department of anatomical sciences, school of medicine, isfahan university of medical sciences, isfahan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
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| نشانی اینترنتی |
http://www.anatomyjournal.ir/browse.php?a_code=A-10-73-2&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
3 |
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