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Anatomical Sciences Journal، جلد ۱۲، شماره ۳، صفحات ۱۳۷-۱۴۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Vitamin C Can Alter Lead-Induced Passive Avoidance Learning Impairment in Rats |
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| چکیده انگلیسی مقاله |
Introduction: Lead (Pb) is a neurotoxin that its different effects on the central nervous system are well-known. Previous studies have reported the potent effects of vitamin C on memory.The present study was undertaken to evaluate the protective effects of vitamin C against leadinduced amnesia. Methods: Male Wistar rats were divided into 4 groups: the control (saline), negative control (lead), positive control (Vitamin C, 150 mg/kg), and experimental (Lead+Vitamin C). To induce lead toxicity, the rats received water containing 0.2% Pb instead of regular water for 1 month. Passive avoidance learning was assessed by Shuttle Box 2 months later. Retention was tested 24 hours after training. Results: The results showed that lead causes impairment in acquisition and retrieval processes of passive avoidance learning and memory. However, vitamin C administration reinforced passive avoidance learning and memory. All results were significant (P< 0.001). Conclusion: Vitamin C administration in rats counteracts the negative effect of lead on spatial learning and memory. |
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| کلیدواژههای انگلیسی مقاله |
Lead, Vitamin C, Passive avoidance learning, Rats. |
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| نویسندگان مقاله |
ایرج صالحی | iraj salehi
hums
مریم شهاب سلیمانی | maryam shahab soleimani
hums
مونا پورجعفر | mona pourjafar
hums
فهیمه قاسمی مروج | fahimeh ghasemi moravej
hums
سارا سلیمانی اصل | sara soleimani asl
department of anatomy, school of medicine, hamedan university of medical sciences, hamedan, iran.
سازمان های دیگر: Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
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| نشانی اینترنتی |
http://www.anatomyjournal.ir/browse.php?a_code=A-10-112-1&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
1 |
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