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Anatomical Sciences Journal، جلد ۱۱، شماره ۴، صفحات ۱۶۳-۱۶۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effects of L-Arginine and L-NAME on Duodenal Histologic Parameters in Female Wistar Rats |
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| چکیده انگلیسی مقاله |
Introduction: Nitric oxide (NO), as a free radical, involves in several physiologic functions in GI tract such as nerve impulse transmission and vascular tonicity regulation. Nitric oxide synthase (NOS) is the enzyme for the production of NO from L-Arginine which in turn inhibits by L-NGNitroarginine Methyl Ester (L-NAME). In the current work, we aimed to evaluate morphometric analysis of duodenum under exposure of L-Arginine and L-NAME in female Wistar rats. Methods: In this study, 5 groups (N=8) of 40 female rats (200-250 g, 8 weeks age) were chosen. Normal saline (2 mL/kg), L-Arginine (200 mg/kg), L-NAME (20 mg/kg) and L-Arginine+LNAME (with the same doses) were administered intraperitoneal — for 3 days. After 2 weeks, samples were collected, stained with hematoxylin and eosin (H&E) and observed under light microscopy. Duodenal epithelial cell height and number, gland diameter, and submucosal and muscular thicknesses were measured using optical software and analyzed by one-way ANOVA followed by Tukey’s post hoc test using SPSS-16. P≤ 0.05 was considered statistically significant. Results: There were no significant changes in mean variables compared to the control group. Conclusion: The results attested no noticeable changes in regard with the effects of L-arginine and L-NAME on duodenum parameters despite the major roles of NO in GI tract. |
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| کلیدواژه‌های انگلیسی مقاله |
Duodenum, Nitric oxide, L-arginine, Rat |
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| نویسندگان مقاله |
فاطمه sabbaghziarani | fatemeh sabbaghziarani
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
کیوان مرتضایی | keywan mortezaee
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
غلامرضا حسن زاده | golamreza hassanzadeh
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سید محمد حسین نوری موگهی | seyed mohammad hossein noori mugahi
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
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| نشانی اینترنتی |
http://www.anatomyjournal.ir/browse.php?a_code=A-10-57-2&slc_lang=en&sid=en |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
1 |
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