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Anatomical Sciences Journal، جلد ۱۱، شماره ۴، صفحات ۱۸۳-۱۸۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Cytotoxic Effects of Digoxin on Mesenchymal Stem Cells: An in Vitro Study |
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| چکیده انگلیسی مقاله |
Introduction: Cardiac glycosides such as digoxin or digitoxin are the natural products that are traditionally used to increase cardiac contractile force in patients with heart failure and cardiac arrhythmias. It has been shown that digoxin can directly inhibit the cell proliferation and lead to cell apoptosis. Present study was conducted to analyze the effect of digoxin in the cohorts of mesenchymal stem cells(MSCs) -based therapy. Methods: MSCs were cultured and treated with different concentrations (0.1, 0.5, 1, 5, 7, 10, 15, 20, 30 and 40 μM) of digoxin for 6, 12, 24 and 48 hours. MTT assay was performed to study cell viability and proliferation. Results: After 24 and 48 hours, cell viability was significantly decreased in 20, 30 and 40 μM concentrations (P< 0.05), but significant decline in cell viability was observed only in 40 μM after 12 hours (P< 0.05). After 6 hours, cell viability of experimental groups had no significant differences toward control group (P>0.05). Conclusion: It is suggested that digoxin may lead to decline in cell survival ability and increase in cell apoptosis in a dose-time dependent pattern. It is recommended to consider application of glycosoids in concurrence with stem cell therapy. |
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| کلیدواژههای انگلیسی مقاله |
Mesenchymal stem cell, Digoxin, MTT, Cell proliferation |
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| نویسندگان مقاله |
هوشنگ رفیقدوست | hooshang rafighdoust
organization
آمنه محمدی روشنده | amaneh mohammadi roushandeh
organization
شیرین دارابی | shirin darabi
department of anatomical sciences, school of medicine, zahehan university of medical sciences, zahedan, iran.
مطهره مرتضوی | motahareh mortazavi
organization
امیر رفیقدوست | amir rafighdoust
organization
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| نشانی اینترنتی |
http://www.anatomyjournal.ir/browse.php?a_code=A-10-85-2&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
1 |
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