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Iranian Rehabilitation Journal، جلد ۹، شماره ۲، صفحات ۴۵-۵۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Identification of Genetic Polymorphism Interactions in Sporadic Alzheimer’s Disease Using Logic Regression |
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| چکیده انگلیسی مقاله |
Objectives: Genetic polymorphism interactions are among the important factors in affliction with complex diseases like Alzheimer’s disease. The important goal of genetic association studies is to identify a combination of polymorphisms and measure their importance in increasing the risk of occurrence of such diseases. In this study, feature selection approach of logic regression was used to identify the interactions among genetic polymorphisms influential in patients affected with Alzheimer’s disease. Methods: 101 Alzheimer’s cases and 109 control subjects from Iranian population were recruited in a case-control study. The evaluation of genes in two groups was performed using molecular technique methods in particular, the PCR-RFLP technique was used to evaluate the intended polymorphisms in APOE, ABCA1, CALHM, CCR2, GSK3β, SAITOHIN, TAU, TNF-α and VDR genes, and then the feature selection approach was used to detect the significance polymorphisms and interactions between them. Results: Based on feature selection approach, the two-way interaction between the polymorphisms of SAITOHIN and APOE genes were significant on occurrence of Alzheimer’s disease. Discussion: Logic regression approach is recommended to detect interaction in the genetic association studies. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
نجیمه ترکش اصفهانی | najimeh tarkesh esfahani
university of social welfare and rehabilitation sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم بهزیستی و توانبخشی (University of social welfare and rehabilitation sciences)
مهدی رهگذر | mehdi rahgozar
university of social welfare and rehabilitation sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم بهزیستی و توانبخشی (University of social welfare and rehabilitation sciences)
اکبر بیگلریان | akbar biglarian
university of social welfare and rehabilitation sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم بهزیستی و توانبخشی (University of social welfare and rehabilitation sciences)
حمیدرضا خرم خورشید | hamid reza khorram khorshid
genetic research center, university of social welfare and rehabilitation, tehran, iran.
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| نشانی اینترنتی |
http://irj.uswr.ac.ir/browse.php?a_code=A-10-200-1&slc_lang=en&sid=en |
| فایل مقاله |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
original articles |
| نوع مقاله منتشر شده |
پژوهشی |
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