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Basic and Clinical Neuroscience، جلد ۷، شماره ۳، صفحات ۲۰۳-۲۱۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Age-Related Differences in Neuropathic Pain Behavior and Spinal Microglial Activity after L5 Spinal Nerve Ligation in Male Rats |
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| چکیده انگلیسی مقاله |
Introduction: Several studies have reported the involvement of age-related changes in the development of neuropathic pain behaviors. However, limited data are available on the role of age in establishing and maintaining chronic neuropathic pain after peripheral nerve injury. Methods: In the present study, we examined age-related neuropathic behavior among rats in 4 age groups: pups (4 weeks old; weight, 60–80 g), juvenile rats (6 weeks old; weight, 120–140 g), and mature rats (10–12 weeks old; weight, 200–250 g). Because the exact contribution of spinal microglia and its association with the development of neuropathic pain remains unknown, we also evaluated the expression of spinal Iba1, a microglial marker, by using western blotting before and 5 days after spinal nerve ligation (SNL) as well as after the daily IP administration of minocycline (30 mg/kg). Results: Our results showed that SNL-induced mechanical allodynia but not thermal hyperalgesia in mature rats but not in pups (P< 0.05 and P< 0.01, respectively). The expression of spinal Iba1 in the juvenile rats was significantly lower than that in pups and mature rats (P< 0.01). Moreover, administration of minocycline decreased the expression of spinal Iba1 in the pup rats more than in juvenile rats (P< 0.001) and in the juvenile rats more than in the mature rats (P< 0.05). Conclusion: These data suggest that the development of neuropathic behaviors and microglial activation after SNL could be age dependent. |
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| کلیدواژههای انگلیسی مقاله |
Age- related, Hyperalgesia, Allodynia, Iba1 |
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| نویسندگان مقاله |
حسین زینالی | hossien zeinali
shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
هما مناهجی | homa manaheji
neurophysiology research center, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
جلال زرین قلم | jalal zaringhalam
shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
زهرا بهاری | zahra bahari
shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
صمد ناظمی | samad nazemi
sabzevar university of medical sciences, iran
مهدی صادقی | mehdi sadeghi
boushehr university of medical sciences, iran
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-710-1&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
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