Basic and Clinical Neuroscience، جلد ۷، شماره ۳، صفحات ۲۲۱-۲۳۰
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Neural Correlates of Craving in Methamphetamine Abuse
چکیده انگلیسی مقاله Introduction: Methamphetamine is a powerful psychostimulant that causes significant neurological impairments with long-lasting effects and has provoked serious international concerns about public health. Denial of drug abuse and drug craving are two important factors that make the diagnosis and treatment extremely challenging. Here, we present a novel and rapid noninvasive method with potential application for differentiation and monitoring methamphetamine abuse. Methods: Visual stimuli comprised a series of images with neutral and methamphetamine-related content. A total of 10 methamphetamine abusers and 10 age-gender matched controls participated in the experiments. Event-related potentials (ERPs) were recorded and compared using a time window analysis method. The ERPs were divided into 19 time windows of 100 ms with 50 ms overlaps. The area of positive sections below each window was calculated to measure the differences between the two groups. Results: Significant differences between two groups were observed from 250 to 500 ms (P300) in response to methamphetamine-related visual stimuli and 600 to 800 ms in response to neutral stimuli. Conclusion: This study presented a novel and noninvasive method based on neural correlates to discriminate healthy individuals from methamphetamine drug abusers. This method can be employed in treatment and monitoring of the methamphetamine abuse.
کلیدواژه‌های انگلیسی مقاله Event-related potential, Brain, Methamphetamine, Craving
نویسندگان مقاله فانک شاه محمدی | fanak shahmohammadi
department of computer engineering, islamic azad university, tehran north branch, tehran, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

مهرشاد گلسرخی | mehrshad golesorkhi
translational neuroscience program, institute for cognitive science studies, tehran, iran.


محمد منصور ریاحی کاشانی | mohammad mansour riahi kashani
department of computer engineering, islamic azad university, tehran north branch, tehran, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

مهرداد سنگی | mehrdad sangi
auckland bioengineering institute, university of auckland, auckland, new zealand.


احمد یونسی | ahmad yoonessi
mcgill vision research, mcgill university, montreal, qc, canada.


علی یونسی | ali yoonessi
department of neuroscience, school of advanced technologies in medicine, tehran university of medical sciences, italy ave., tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-681-1&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cognitive Neuroscience
نوع مقاله منتشر شده Original
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