| چکیده انگلیسی مقاله |
Introduction: To study the effect of gallic acid (GA) on hippocampal long-term potentiation (LTP) and histological changes in animal model of Alzheimer disease (AD) induced by betaamyloid (Aβ). Methods: Sixty-four adult male Wistar rats (300±20 g) were divided into 8 groups: 1) Control (Cont); 2) AD; 3) Sham; 4-7) AD+GA (50, 100, and 200 mg/kg for 10 days, orally) or vehicle, 8) Cont+GA100, Aβ (1μg/μL in each site) was infused into hippocampus bilaterally. Changes of amplitude and slope of LTP induced in hippocampal dentate gyrus (DG) were evaluated by high frequency stimulation (HFS) of perforant path (PP). Results: Data showed that LTP amplitude and area under curve significantly impaired in AD rats (P< 0.001), while significantly improved in AD rats treated with GA (P< 0.05, P< 0.01). Conclusion: Current findings suggest that GA reduces neural damage and brain amyloid neuropathology and improves cognitive function via free radicals scavenging and inhibiting oligomerization of Aβ but with no effect on healthy rats. |
| نویسندگان مقاله |
سمیه حاجی پور | somayeh hajipour
physiology research center, department of physiology, school of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)
علیرضا سرکاکی | alireza sarkaki
golestan blvd., , ahvaz jundishapur university of medical sciences, ahvaz-iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)
یعقوب فربود | yaghoob farbood
golestan blvd., , ahvaz jundishapur university of medical sciences, ahvaz-iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)
اکرم عیدی | akram eidi
department of biology, sciences amp;amp; researches branch, islamic azad university, tehran-iran.
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
پژمان مرتضوی | pejman mortazavi
dept. of pathology, faculty of specialized veterinary science, science amp;amp; research branch, islamic azad university, tehran-iran.
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
زهره ولی زاده | zohreh valizadeh
department of nursing and midwifery, dezfoul branch, islamic azad university, dezfoul, iran.
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
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