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Basic and Clinical Neuroscience، جلد ۷، شماره ۱، صفحات ۲۱-۳۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Protection of Hippocampal CA1 Neurons Against Ischemia/Reperfusion Injury by Exercise Preconditioning via Modulation of Bax/ Bcl-2 Ratio and Prevention of Caspase-3 Activation |
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| چکیده انگلیسی مقاله |
Introduction: Ischemia leads to loss of neurons by apoptosis in specific brain regions, especially in the hippocampus. The purpose of this study was investigating the effects of exercise preconditioning on expression of Bax, Bcl-2, and caspase-3 proteins in hippocampal CA1 neurons after induction of cerebral ischemia. Methods: Male rats weighing 260-300 g were randomly allocated into three groups (sham, exercise, and ischemia). The rats in exercise group were trained to run on a treadmill 5 days a week for 4 weeks. Ischemia was induced by the occlusion of both common carotid arteries (CCAs) for 20 min. Levels of expression of Bax, Bcl-2, and caspase-3 proteins in CA1 area of hippocampus were determined by immunohistochemical staining . Results: The number of active caspase-3-positive neurons in CA1 area were significantly increased in ischemia group, compared to sham-operated group (P< 0.001), and exercise preconditioning significantly reduced the ischemia/reperfusion-induced caspase-3 activation, compared to the ischemia group (P< 0.05). Also, results indicated a significant increase in Bax/Bcl-2 ratio in ischemia group, compared to sham-operated group (P< 0.001). Discussion: This study indicated that exercise has a neuroprotective effects against cerebral ischemia when used as preconditioning stimuli. |
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| کلیدواژههای انگلیسی مقاله |
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| نویسندگان مقاله |
ناهید ابوطالب | nahid aboutaleb
organization
نبی شمسایی | nabi shamsaei
department of physical education amp;amp; sports sciences, faculty of literature and humanities, ilam university, ilam, iran.
سازمان اصلی تایید شده: دانشگاه ایلام (Ilam university)
حمید رجبی | hamid rajabi
organization
مهدی خاکساری | mehdi khaksari
organization
سهیلا عرفانی | sohaila erfani
organization
فرناز نیکبخت | farnaz nikbakht
organization
پژمان معتمدی | pezhman motamedi
organization
علی شهبازی | ali shahbazi
organization
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-766-1&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
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