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Basic and Clinical Neuroscience، جلد ۶، شماره ۴، صفحات ۲۷۱-۲۸۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Exploring Neural Correlates of Different Dimensions in Drug Craving Self-Reports among Heroin Dependents |
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| چکیده انگلیسی مقاله |
Introduction: Drug craving could be described as a motivational state which drives drug dependents towards drug seeking and use. Different types of self-reports such as craving feeling, desire and intention, wanting and need, imagery of use, and negative affect have been attributed to this motivational state. By using subjective self-reports for different correlates of drug craving along with functional neuroimaging with cue exposure paradigm, we investigated the brain regions that could correspond to different dimensions of subjective reports for heroin craving. Methods: A total of 25 crystalline-heroin smokers underwent functional magnetic resonance imaging (fMRI), while viewing heroin-related and neutral cues presented in a block-design task. During trial intervals, subjects verbally reported their subjective feeling of cue induced craving (CIC). After fMRI procedure, participants reported the intensity of their “need for drug use” and “drug use imagination” on a 0-100 visual analog scale (VAS). Afterwards, they completed positive and negative affect scale (PANAS) and desire for drug questionnaire (DDQ) with 3 components of “desire and intention to drug use,” “negative reinforcement,” and “loss of control.” Results: The study showed significant correlation between “subjective feeling of craving” and activation of the left and right anterior cingulate cortex, as well as right medial frontal gyrus. Furthermore, the “desire and intention to drug use” was correlated with activation of the left precentral gyrus, left superior frontal gyrus, and left middle frontal gyrus. Subjects also exhibited significant correlation between the “need for drug use” and activation of the right inferior temporal gyrus, right middle temporal gyrus, and right parahippocampal gyrus. Correlation between subjective report of “heroin use imagination” and activation of the cerebellar vermis was also observed. Another significant correlation was between the “negative affect” and activation of the left precuneus, right putamen, and right middle temporal gyrus. Discussion: This preliminary study proposes different neural correlates for various dimensions of subjective craving self-reports. It could reflect multidimensionality of cognitive functions corresponding with drug craving. These cognitive functions could represent their motivational and affective outcomes in a single item “subjective craving feeling” or in self-reports with multiple dissociable items, such as intention, need, imagination, or negative feeling. The new psychological models of drug craving for covering various dimensions of subjective craving self-reports based on their neurocognitive correspondence could potentially modify craving assessments in addiction medicine. |
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| کلیدواژههای انگلیسی مقاله |
Craving, Self-report, Heroin, fMRI |
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| نویسندگان مقاله |
پیمان حسنی ابهریان | peyman hassani abharian
tehran university of medical sciences, imam khomeini hospital, keshavarz blv, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
حبیب گنجگاهی | habib ganjgahi
tehran university of medical sciences, imam khomeini hospital, keshavarz blv, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
حسین طباطبایی جعفری | hosein tabatabaei jafari
tehran university of medical sciences, imam khomeini hospital, keshavarz blv, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
محمد علی عقابیان | mohammad ali oghabian
tehran university of medical sciences, imam khomeini hospital, keshavarz blv, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
آذرخش مکری | azarakhsh mokri
tehran university of medical sciences, imam khomeini hospital, keshavarz blv, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
حامد اختیاری | hamed ekhtiari
neuroimaging and analysis group niag , research center for molecular and cellular imaging, tehran university of medical sciences, imam khomeini hospital, keshavarz blv, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-194-1&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cognitive Neuroscience |
| نوع مقاله منتشر شده |
Original |
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