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Basic and Clinical Neuroscience، جلد ۵، شماره ۴، صفحات ۲۴۶-۲۵۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Modulatory Effects of Dopamine D2 Receptors on Spreading Depression in Rat Somatosensory Neocortex |
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| چکیده انگلیسی مقاله |
Introduction: Spreading depression (SD) is a propagating wave of depolarization followed by depression of the neuroglial activities and can modulate extracellular dopamine concentrations in the neocortex. It has been shown that the dopaminergic system plays a role in migraine. SD has been suggested as a critical phenomenon in the pathophysiology of migraine. The aim of this study was to investigate the effect of dopamine D2 receptors on the characteristic features of SD in rat neocortical tissues. Methods: The effect of dopamine D2 receptor agonist quinpirole and D2 receptor antagonist sulpiride was tested on different characteristic features (amplitude, duration and velocity) of KCl-induced SD in somatosensory neocortical slices of adult rats. The effect of above-mentioned substances on production of long-term potentiation (LTP) in the neocortex was also evaluated. Results: The present data revealed a dose-dependent suppression of the amplitude and duration of SD in the presence of the dopamine D2 receptor antagonist sulpiride in the neocortex. D2 dopamine receptor agonist quinpirole dose-dependently enhanced the amplitude and duration of the neocortical SD. Furthermore, application of D2 receptor antagonist significantly suppressed induction of LTP. Discussion: These results indicate that D2 receptors modulate the initiation of SD in the neocortex. This finding refers to the potential role of D2 receptor antagonist in treatment of migraine pain. |
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| کلیدواژههای انگلیسی مقاله |
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| نویسندگان مقاله |
آناماریا haarmann | anna maria haarmann
institute of neurophysiology, westfälische wilhelms-universität münster, germany.
مریم جعفریان | maryam jafarian
shefa neuroscience research center, tehran, iran.
سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)
فریبا کریم زاده | fariba karimzadeh
school of advanced medical technology, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
علی گرجی | ali gorji
epilepsy research center, westfälische wilhelms-universität münster, germany.
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-535-1&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
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