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Basic and Clinical Neuroscience، جلد ۳، شماره ۵، صفحات ۱۹-۲۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Involvement of Nitric Oxide System on Anxiolytic-Like Behaviors Induced by Cholestasiss |
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| چکیده انگلیسی مقاله |
Introduction: The mechanisms of hepatic encephalopathy are not fully understood. Moreover, there is no comprehensive data concerning the effects of nitric oxide (NO) system on anxiolytic-like behaviors induced by bile duct ligation (BDL). Methods: Male mice weighing 25-30 g were used and anxiety-like behaviors were tested using hole-board task. Results: The data indicated that cholestasis increased the number of head-dipping but did not alter other aspects of behavior, 7 days after BDL, suggesting an anxiolytic-like response. Furthermore, the results showed that intraperitoneal (i.p.) injection of L-arginine (200 and 250 mg/kg) 15 min before testing induced anxiolytic-like behaviors in the normal animals, 4 and 7 days after BDL (considering that the dose of 200 mg in the normal mice is ineffective but is effective in the BDL mice). On the other hand, injection of L-NAME (35 and 45 mg/kg, i.p.) 15 min before testing induced anxiogenic-like behaviors in the normal animals, 4 and 7 days after BDL (the dose of 35 mg/kg in the normal mice is ineffective but is effective in the BDL mice ). Moreover, injection of ineffective doses of L-NAME (25 and 35 mg/kg, i.p.) 15 min before administration of L-arginine (250 mg/kg, i.p.) and 7 days after BDL, decreased anxiolytic-like behaviors, signi.cantly. Discussion: Cholestatic mice show anxiolytic-like behaviors suggesting the involvement of the nitric oxide system. |
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| نویسندگان مقاله |
محمد ناصحی | mohammad nasehi
وحید صبوری خانقاه | vahid sabouri khanghah
سپیده میرزایی ورزقانی | sepideh mirzaei varzeghani
محمدرضا زرین دست | mohammad reza zarrindast
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-127&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cellular and molecular Neuroscience |
| نوع مقاله منتشر شده |
Original |
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