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Basic and Clinical Neuroscience، جلد ۳، شماره ۱، صفحات ۴۸-۵۷
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Varenicline Ameliorates Learning and Memory Deficits in Amyloid β(25–35) Rat Model of Alzheimer’s Disease |
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| چکیده انگلیسی مقاله |
Introduction: Alzheimer’s disease (AD) is a enfeeble neurodegenerative disorder characterized by increased β-amyloid (Aβ) deposition and neuronal dysfunction leading to impaired learning and recall. Among proposed risk factors, impaired cholinergic transmission is a main cause for incidence of disease. Methods: In the present study, effects of the intracerebroventricularly administration of an agonist of nicotinic cholinergic receptors, varenicline(0.5 and 2 μg/μl), on learning and memory impairments induced by intrahippocampal Aβ(25–35) injection was assessed in rats. Results: The results showed that the intrahippocampal Aβ(25–35) injected rats exhibit lower spontaneous alternation score inY-maze tasks (p< 0.05), impaired retention and recall capability in the passive avoidance test (p< 0.05), and fewer correct choices (p< 0.001) and more errors(p< 0.001) in the RAM task. Varenicline, almost in both doses, significantly improved alternation score in Y-maze task (p< 0.001), impaired retention and recall capability in the passive avoidance test (p< 0.05), and correct choices in the RAM task (p< 0.001). Discussion: This study indicates that varenicline pretreatment attenuates Aβ- induced impairment of short-term spatial memory in rats probably due to its agonist activity at nicotinic receptors. |
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| نویسندگان مقاله |
توراندخت بلوچ نژاد مجرد | tourandokht baluchnejadmojarad
مهرداد روغنی | mehrdad roghani
نرگس کریمی | narges karimi
میترا کامران | mitra kamran
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-92&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Clinical Neuroscience |
| نوع مقاله منتشر شده |
Original |
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